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利用初级保健数据了解阿片类药物处方、政策影响和临床结果:OPPICO 研究方案。

Using primary care data to understand opioid prescribing, policy impacts and clinical outcomes: A protocol for the OPPICO study.

机构信息

Monash Addiction Research Centre, Eastern Health Clinical School, Monash University, 47-49 Moorooduc Hwy, Frankston, VIC, 3128, Australia; Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, 381 Royal Parade Parkville, Melbourne, VIC, 3052, Australia.

Monash Addiction Research Centre, Eastern Health Clinical School, Monash University, 47-49 Moorooduc Hwy, Frankston, VIC, 3128, Australia.

出版信息

Res Social Adm Pharm. 2022 Dec;18(12):4129-4137. doi: 10.1016/j.sapharm.2022.07.041. Epub 2022 Jul 31.

Abstract

INTRODUCTION

Prescription opioid use in Australia has increased over the last 3 decades. The majority of opioids are prescribed and dispensed in primary care, however, there are few studies that are specific to opioid prescribing in this setting. Evidence about the impact of key government policy strategies to optimize opioid prescribing in primary care is limited. The aim of this study is to examine the impact of recent policy changes and clinical guidelines on opioid prescribing in primary care.

METHODS AND ANALYSIS

Longitudinal analysis of people prescribed opioid analgesics using Population Level Analysis and Reporting (POLAR) data. POLAR is a primary care dataset comprising 464 primary health care practices in Victoria, Australia. People prescribed opioid analgesics between 2015 and 2020 will be included. The impact of opioid policies and guideline recommendations will be evaluated using interrupted time series models. Group- based trajectory modelling and multivariate regression will be used to identify patterns of opioid cessation and the provision of corresponding non-opioid interventions.

ETHICS AND DISSEMINATION

The study has received Monash University Human Research Ethics Committee approval (ID 24139). Permission to access, collate and use POLAR data is granted from Outcome Health as the data custodians. The results of this study will be disseminated through publication in international journals, presented at national and international scientific conferences, and disseminated to consumers, policy makers, primary care providers and primary health networks.

PROTOCOL REGISTRATION DETAILS

EU PAS Register (EUPAS43218).

摘要

简介

在过去的 30 年中,澳大利亚的处方类阿片药物使用量有所增加。大多数阿片类药物都是在初级保健中开具和分发的,然而,针对这一背景下的阿片类药物开具处方的研究却很少。关于优化初级保健中阿片类药物开具处方的主要政府政策策略的效果的证据有限。本研究旨在检验近期政策变化和临床指南对初级保健中阿片类药物开具处方的影响。

方法和分析

使用人群水平分析和报告(POLAR)数据对开具阿片类镇痛药处方的人群进行纵向分析。POLAR 是一个初级保健数据集,包含澳大利亚维多利亚州的 464 个初级保健实践。将纳入 2015 年至 2020 年期间开具阿片类镇痛药处方的人群。将使用中断时间序列模型评估阿片类药物政策和指南建议的影响。群组轨迹建模和多变量回归将用于确定阿片类药物停药模式和提供相应的非阿片类药物干预措施。

伦理和传播

本研究已获得莫纳什大学人类研究伦理委员会的批准(ID 24139)。Outcome Health 作为数据保管人授予了访问、整理和使用 POLAR 数据的许可。本研究的结果将通过在国际期刊上发表、在国家和国际科学会议上展示以及向消费者、政策制定者、初级保健提供者和初级卫生网络传播来传播。

协议注册详情

EU PAS 登记(EUPAS43218)。

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