Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA.
IRCCS Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy.
J Neuroimmunol. 2022 Oct 15;371:577948. doi: 10.1016/j.jneuroim.2022.577948. Epub 2022 Aug 6.
The aim of this investigation was to determine if particular immunoglobulin GM (γ marker) alleles and genotypes were associated with Parkinson's disease (PD) and whether they contributed to the interindividual differences in the level of antibodies to herpes simplex virus type 1 (HSV1), which has been implicated in PD pathology. Using a case-control study design, 94 PD patients and 157 controls were characterized for anti-HSV1 IgG antibodies and genotyped for GM alleles expressed on IgG1 (3,17) and IgG2 (23 +, 23-). The homozygosity for the GM 3 and GM 23 alleles was significantly associated with susceptibility to PD (p = 0.004, 0.018, respectively). Also, GM 23 genotypes were significantly associated with anti-HSV1 IgG antibody levels in patients (p = 0.0021), but not in controls. These results suggest that GM genes may act as effect modifiers of the reported HSV1-PD association.
本研究旨在确定特定免疫球蛋白 GM (γ 标志物) 等位基因和基因型是否与帕金森病 (PD) 相关，以及它们是否导致对单纯疱疹病毒 1 (HSV1) 的抗体水平的个体间差异，HSV1 已被牵连到 PD 病理学中。采用病例对照研究设计，对 94 名 PD 患者和 157 名对照者进行抗 HSV1 IgG 抗体特征分析，并对 IgG1(3,17)和 IgG2(23 +, 23-) 上表达的 GM 等位基因进行基因分型。GM 3 和 GM 23 等位基因的纯合性与 PD 的易感性显著相关 (p = 0.004，0.018，分别)。此外，GM 23 基因型与患者的抗 HSV1 IgG 抗体水平显著相关 (p = 0.0021)，但与对照组无关。这些结果表明，GM 基因可能是报道的 HSV1-PD 关联的效应修饰因子。
