ANXA5 在复发性妊娠丢失中的研究进展。
Research progress on ANXA5 in recurrent pregnancy loss.
机构信息
Department of Reproductive Immunology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China; Shanghai Key Laboratory of Maternal and Fetal Medicine, Shanghai First Maternity & Infant Hospital, Shanghai 201204, China.
Department of Medical Genetics, The First Rehabilitation Hospital of Shanghai, School of Medicine, Tongji University, Shanghai 200092, China.
出版信息
J Reprod Immunol. 2022 Sep;153:103679. doi: 10.1016/j.jri.2022.103679. Epub 2022 Jul 28.
The incidence of recurrent pregnancy loss (RPL) in fertile women ranges from 1% to 5%, of which about 50% of them are due to unknown causes. The possible pathogenesis of RPL is an urgent problem to be solved in the clinical. Mutations or polymorphisms of certain genes in the coagulation mechanism are associated with susceptibility to thrombotic diseases and are one of the main reasons for the occurrence of RPL. Among them, the ANXA5 gene was newly studied and some single nucleotide polymorphisms (SNPs) in the promoter region of ANXA5 have been reported to be associated with RPL in multiple races. In this review, we summarized the research progress on the correlation between the SNPs in ANXA5 and RPL, hoping to provide some valuable guidance for the future studies.
复发性妊娠丢失（RPL）在生育期妇女中的发生率为 1%至 5%，其中约 50%的病因不明。RPL 的可能发病机制是临床亟待解决的问题。凝血机制中某些基因的突变或多态性与血栓性疾病的易感性有关，是 RPL 发生的主要原因之一。其中，ANXA5 基因是新研究的基因，已有报道称 ANXA5 启动子区域的某些单核苷酸多态性（SNP）与多种种族的 RPL 有关。在本综述中，我们总结了 ANXA5 中 SNP 与 RPL 之间相关性的研究进展，希望为今后的研究提供一些有价值的指导。
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