Quebec Heart and Lung Institute - UL, Québec, Québec, Canada.
Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, New South Wales, Australia; Priority Research Centre for Healthy Lungs, The University of Newcastle, Newcastle, New South Wales, Australia.
Immunol Allergy Clin North Am. 2022 Aug;42(3):507-519. doi: 10.1016/j.iac.2022.04.007.
Much interest has been given to the asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) in the past 2 decades, but the condition is still ill-defined. There is general agreement that a patient with longstanding asthma who develops fixed airflow obstruction after years of smoking has ACO although defining asthma in the face of COPD can be challenging. Many features of asthma are also found in patients with COPD without indicating an overlap and no consensus exists on which characteristics should be included in the definition of ACO. Nevertheless, some guidance has been issued to help clinicians and researchers to make a diagnosis of ACO and these will be reviewed here.
在过去的 20 年中，人们对哮喘-慢性阻塞性肺疾病（COPD）重叠（ACO）产生了浓厚的兴趣，但这种情况仍然定义不清。人们普遍认为，患有长期哮喘的患者在吸烟多年后发展为固定气流阻塞，即为 ACO，尽管在 COPD 面前定义哮喘可能具有挑战性。许多哮喘的特征也存在于没有表明重叠的 COPD 患者中，并且对于应包括在 ACO 定义中的哪些特征也没有共识。尽管如此，已经发布了一些指导意见，以帮助临床医生和研究人员对 ACO 做出诊断，本文将对此进行回顾。
