Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, 2725, Chemin Sainte-Foy, Québec, Québec G1V 4G5, Canada.
Immunol Allergy Clin North Am. 2022 Aug;42(3):549-558. doi: 10.1016/j.iac.2022.03.002.
The diagnosis of asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) is considered when a patient presents features of both asthma and COPD, usually including a component of irreversible airway obstruction (IRAO). However, some patients with asthma, particularly smokers, may have various features typical of COPD in the absence of such component of IRAO. Features of early COPD can be found at a young age in such patients even with normal spirometry. More longitudinal studies should be conducted to determine steps needed to improve clinical outcomes of these patients including the early recognition of these changes and the application of preventative/therapeutic interventions.
当患者同时表现出哮喘和 COPD 的特征时，通常包括不可逆气道阻塞 (IRAO) 的成分，就会考虑哮喘-慢性阻塞性肺疾病 (COPD) 重叠 (ACO) 的诊断。然而，一些哮喘患者，特别是吸烟者，即使没有 IRAO 的成分，也可能具有各种典型的 COPD 特征。在这些患者中，即使肺功能正常，也可能在年轻时就出现早期 COPD 的特征。应该进行更多的纵向研究，以确定改善这些患者临床结果所需的措施，包括早期识别这些变化和应用预防/治疗干预措施。
