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35岁及以下因良性妇科疾病接受子宫切除术患者的生活质量和性功能:一项前瞻性队列研究。

Quality of life and sexual function in patients aged 35 years or younger undergoing hysterectomy for benign gynecologic conditions: A prospective cohort study.

作者信息

Zimmermann Julia S M, Sima Romina-Marina, Radosa Marc P, Radosa Christoph G, Ples Liana, Wagenpfeil Stefan, Solomayer Erich-Franz, Radosa Julia C

机构信息

Department of Gynecology and Obstetrics, Saarland University Hospital, Homburg, Germany.

Department of Gynecology and Obstetrics, Klinikum Bremen-Nord, Bremen, Germany.

出版信息

Int J Gynaecol Obstet. 2023 Feb;160(2):548-553. doi: 10.1002/ijgo.14400. Epub 2022 Sep 1.

Abstract

OBJECTIVE

To evaluate how hysterectomy performed for benign gynecologic pathologies affects the quality of life and sexual function of patients aged 35 years or younger, and if outcomes differ according to the surgical technique.

METHODS

Seventy-three patients who underwent total laparoscopic hysterectomy (TLH), supracervical laparoscopic hysterectomy (SLH), or vaginal hysterectomy (VH) for benign uterine disorders between April 2014 and June 2020 at the Department of Gynecology and Obstetrics, Saarland University Hospital, Homburg, Germany, were enrolled in this prospective observational cohort study. Quality of life and sexual function were assessed preoperatively and 6 months postoperatively using standardized validated questionnaires: the European Quality of Life Five-Dimension Scale (EQ-5D) and the Female Sexual Function Index (FSFI).

RESULTS

Thirty-three (45%) patients underwent TLH, 25 (34%) underwent SLH, and 15 (21%) patients underwent VH. The median preoperative EQ-5D score, FSFI score, and EQ-5D visual analog scale were 0.9 (range 0.62-1), 19.25 (range 2.4-27.4), and 50 (range 0-100); postoperative scores were 1 (range 0.61-1), 24.15 (range 3.9-29.3), and 90 (range 30-100), respectively (P ≤ 0.001). Postoperative scores were significantly higher than preoperative scores, with no significant difference according to the surgical technique.

CONCLUSION

Hysterectomy for benign indication in women aged 35 years or less significantly improved the patients' quality of life and sexual function with no differences regarding the surgical technique.

CLINICAL TRIAL REGISTRATION

The study was registered in the German trial registry (no. DRKS00005622).

摘要

目的

评估因良性妇科疾病接受子宫切除术对35岁及以下患者生活质量和性功能的影响,以及手术技术不同结果是否存在差异。

方法

2014年4月至2020年6月期间,在德国洪堡萨尔州大学医院妇产科,73例因良性子宫疾病接受全腹腔镜子宫切除术(TLH)、次全腹腔镜子宫切除术(SLH)或阴道子宫切除术(VH)的患者被纳入这项前瞻性观察队列研究。术前和术后6个月使用标准化验证问卷评估生活质量和性功能:欧洲生活质量五维度量表(EQ-5D)和女性性功能指数(FSFI)。

结果

33例(45%)患者接受TLH,25例(34%)接受SLH,15例(21%)患者接受VH。术前EQ-5D评分、FSFI评分和EQ-5D视觉模拟量表的中位数分别为0.9(范围0.62-1)、19.25(范围2.4-27.4)和50(范围0-100);术后评分分别为1(范围0.61-1)、24.15(范围3.9-29.3)和90(范围30-100)(P≤0.001)。术后评分显著高于术前评分,手术技术方面无显著差异。

结论

35岁及以下女性因良性指征行子宫切除术可显著改善患者生活质量和性功能,手术技术方面无差异。

临床试验注册

该研究已在德国试验注册中心注册(编号DRKS00005622)。

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