College of Acupuncture and Massage, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Provincial Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu, China.
Oxid Med Cell Longev. 2022 Aug 3;2022:2286598. doi: 10.1155/2022/2286598. eCollection 2022.
The aim of the study was to investigate the clinical effects of abdominal massage on patients with type 2 diabetes mellitus (T2DM) and its influence on the intestinal microflora. We conducted a randomized, controlled clinical trial. A total of 60 patients with T2DM, who met the inclusion criteria, were randomly allocated to the control group, the routine massage group, and the abdominal massage group. The control group received health education and maintained their hypoglycemic drug treatment plan. The routine massage group and the abdominal massage group received different massage interventions. In addition to glucose and lipid metabolism indicators, we quantitatively analyzed the gut microbiota to assess the effects of massage on the intestinal microflora of patients with T2DM. Compared with the control group, the abdominal massage improved levels of glycated hemoglobin, total cholesterol, Enterobacter, and Bifidobacteria with significant differences ( = 0.02, = 0.03, = 0.03, and = 0.03). The comparison within group showed that the levels of the four bacterial genera in the abdominal massage group revealed significant differences before and after treatment ( = 0.006, < 0.001, < 0.001, and = 0.002). The comparison between the routine massage group and the abdominal massage group was not significantly different in all levels of test indices. The abdominal massage group regulated levels of Enterobacter and Lactobacilli to a greater extent than the routine massage group. Additionally, abdominal massage decreased Enterococcus levels. The results of this study showed that abdominal massage has clinical advantages over routine massage. Specifically, this intervention may correct microflora disturbances to a certain extent.
本研究旨在探讨腹部按摩对 2 型糖尿病（T2DM）患者的临床疗效及其对肠道菌群的影响。我们进行了一项随机对照临床试验。共纳入符合纳入标准的 60 例 T2DM 患者，随机分为对照组、常规按摩组和腹部按摩组。对照组接受健康教育并维持原有的降糖药物治疗方案，常规按摩组和腹部按摩组分别接受不同的按摩干预。除了血糖和血脂代谢指标外，我们还对肠道微生物群进行了定量分析，以评估按摩对 T2DM 患者肠道微生态的影响。与对照组相比，腹部按摩组显著改善了糖化血红蛋白、总胆固醇、肠杆菌和双歧杆菌水平（=0.02，=0.03，=0.03，=0.03）。组内比较显示，腹部按摩组的这 4 种细菌属水平在治疗前后均有显著差异（=0.006，<0.001，<0.001，=0.002）。常规按摩组与腹部按摩组之间在所有测试指标的水平上比较均无统计学差异。腹部按摩组对肠杆菌和乳酸杆菌的调节作用明显大于常规按摩组，同时降低了肠球菌水平。本研究结果表明，腹部按摩比常规按摩具有临床优势，尤其是在一定程度上纠正了肠道菌群紊乱。
