Petitjean Hugues, Héberlé Eléa, Hilfiger Louis, Łapieś Olga, Rodrigue Guillaume, Charlet Alexandre
Benephyt, Strasbourg, France.
Centre National de la Recherche Scientifique, University of Strasbourg, Institute of Cellular and Integrative Neuroscience, INCI UPR3212, Strasbourg, France.
Front Mol Neurosci. 2022 Jul 29;15:945450. doi: 10.3389/fnmol.2022.945450. eCollection 2022.
The activation of the transient receptor potential (TRP) channels expressed by sensory neurons is essential to the transduction of thermal and mechanical sensory information. In the setting of chronic inflammatory conditions, the activation of the melastatin family member 8 (TRPM8), the TRP vanilloid 1 (TRPV1), and the TRP ankyrin 1 (TRPA1) is correlated with pain hypersensitivity reactions. Monoterpenes, among which pulegone and menthol, a major class of phytocompounds present in essential oils of medicinal plants, are known modulators of those TRP channels activity. In the present review, we correlate the monoterpene content of plants with their historical therapeutic properties. We then describe how monoterpenes exert their anti-inflammatory and antihyperalgesia effects through modulation of TRP channels activity. Finally, we discuss the importance and the potential of characterizing new plant extracts and reassessing studied plant extracts for the development of ethnopharmacology-based innovative treatments for chronic pain. This review suggests that monoterpene solutions, based on composition from traditional healing herbs, offer an interesting avenue for the development of new phytotherapeutic treatments to alleviate chronic inflammatory pain conditions.
感觉神经元表达的瞬时受体电位（TRP）通道的激活对于热和机械感觉信息的转导至关重要。在慢性炎症状态下，褪黑素家族成员8（TRPM8）、TRP香草酸受体1（TRPV1）和TRP锚蛋白1（TRPA1）的激活与疼痛超敏反应相关。单萜类化合物，其中包括胡薄荷酮和薄荷醇，是药用植物精油中存在的一类主要植物化合物，是这些TRP通道活性的已知调节剂。在本综述中，我们将植物的单萜类化合物含量与其历史治疗特性相关联。然后，我们描述单萜类化合物如何通过调节TRP通道活性发挥其抗炎和抗痛觉过敏作用。最后，我们讨论了表征新的植物提取物以及重新评估已研究的植物提取物对于开发基于民族药理学的慢性疼痛创新疗法的重要性和潜力。本综述表明，基于传统草药成分的单萜类化合物溶液为开发新的植物治疗方法以缓解慢性炎症性疼痛状况提供了一条有趣的途径。
