一种负载瑞香素的改良型透明质酸基溶蚀微针改善了银屑病的治疗。
A Modified Hyaluronic Acid-Based Dissolving Microneedle Loaded With Daphnetin Improved the Treatment of Psoriasis.
作者信息
Peng Shiya, Cheng Liuhanghang, Wu Qian, Li Yuanchao, Ran Lei, Wang Wei, Huang Ke, Zhu Rong, Xue Sihong, Zhou Chunli, Zhu Weidong, Cheng Biao, Fu Xiaobing, Wang Rupeng
机构信息
Department of Dermatology and Rheumatology Immunology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department and Fourth Medical Center, PLA General Hospital and PLA Medical College, Beijing, China.
出版信息
Front Bioeng Biotechnol. 2022 Jun 17;10:900274. doi: 10.3389/fbioe.2022.900274. eCollection 2022.
Psoriasis is a common chronic immune-inflammatory disease. Challenges exist in the present treatment of psoriasis, such as difficulties in transdermal drug administration and severe side effects. We hope to achieve a better therapeutic outcome for psoriasis treatment. By using modified soluble microneedles (MNs) loaded with daphnetin, the psoriasis symptoms of mice, the abnormal proliferation of keratinocytes, and the secretion of inflammatory factors were significantly reduced. , daphnetin is proven to inhibit the NF-κB signaling pathway and to inhibit the proliferation of HaCaT cells and the release of inflammatory factors, especially CCL20. This research showed that the modified microneedle loaded with daphnetin optimized transdermal drug delivery and relieved the symptoms of psoriasis more effectively. The novel route of Daph administration provides a future research direction for the treatment of psoriasis.
银屑病是一种常见的慢性免疫炎症性疾病。目前银屑病的治疗存在挑战，如经皮给药困难和严重的副作用。我们希望在银屑病治疗中取得更好的治疗效果。通过使用负载瑞香素的改良可溶性微针（MNs），小鼠的银屑病症状、角质形成细胞的异常增殖以及炎症因子的分泌均显著降低。此外，瑞香素被证明可抑制NF-κB信号通路，抑制HaCaT细胞的增殖和炎症因子尤其是CCL20的释放。本研究表明，负载瑞香素的改良微针优化了经皮给药，更有效地缓解了银屑病症状。瑞香素的新给药途径为银屑病治疗提供了未来的研究方向。
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