Guo Ruimin, Zhao Yunfei, Jin Honghua, Jian Jihua, Wang Haibo, Jin Shengxi, Ren Hongwei
Department of Medical Imaging, Tianyou Hospital of Wuhan University of Science and Technology, Wuhan, China.
Key Laboratory of Occupational Hazards and Identification, Wuhan University of Science and Technology, Wuhan, China.
Front Psychiatry. 2022 Jul 27;13:981728. doi: 10.3389/fpsyt.2022.981728. eCollection 2022.
While abnormal neuroimaging features have been reported in patients suffering from right temporal lobe epilepsy (rTLE), the value of altered degree centrality (DC) as a diagnostic biomarker for rTLE has yet to be established. As such, the present study was designed to examine DC abnormalities in rTLE patients in order to gauge the diagnostic utility of these neuroimaging features. In total, 68 patients with rTLE and 73 healthy controls (HCs) participated in this study. Imaging data were analyzed using DC and receiver operating characteristic (ROC) methods. Ultimately, rTLE patients were found to exhibit reduced right caudate DC and increased left middle temporal gyrus, superior parietal gyrus, superior frontal gyrus, right precuneus, frontal gyrus Inferior gyrus, middle-superior frontal gyrus, and inferior parietal gyrus DC relative to HC. ROC analyses indicated that DC values in the right caudate nucleus could be used to differentiate between rTLE patients and HCs with a high degree of sensitivity and specificity. Together, these results thus suggest that rTLE is associated with abnormal DC values in the right caudate nucleus, underscoring the relevance of further studies of the underlying pathophysiology of this debilitating condition.
虽然已有报道称右侧颞叶癫痫（rTLE）患者存在异常神经影像学特征，但改变的度中心性（DC）作为rTLE诊断生物标志物的价值尚未确立。因此，本研究旨在检查rTLE患者的DC异常情况，以评估这些神经影像学特征的诊断效用。共有68例rTLE患者和73名健康对照者（HCs）参与了本研究。使用DC和受试者工作特征（ROC）方法对影像数据进行分析。最终发现，相对于HCs，rTLE患者右侧尾状核DC降低，左侧颞中回、顶上叶、额上回、右侧楔前叶、额下回、额中-上回及顶下叶DC增加。ROC分析表明，右侧尾状核的DC值可用于以高度敏感性和特异性区分rTLE患者和HCs。总之，这些结果表明rTLE与右侧尾状核DC值异常有关，强调了进一步研究这种使人衰弱病症潜在病理生理学的重要性。
