成人共同性外斜视患者脑网络中心性改变：一项静息态功能磁共振成像研究
Altered brain network centrality in patients with adult comitant exotropia strabismus: A resting-state fMRI study.
作者信息
Tan Gang, Dan Zeng-Renqing, Zhang Ying, Huang Xin, Zhong Yu-Lin, Ye Lin-Hong, Rong Rong, Ye Lei, Zhou Qiong, Shao Yi
机构信息
1 Department of Ophthalmology, First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute and Oculopathy Research Centre, Nanchang, Jiangxi Province, China.
2 Department of Ophthalmology, the First Affiliated Hospital, University of South China, Hengyang, Hunan Province, China.
出版信息
J Int Med Res. 2018 Jan;46(1):392-402. doi: 10.1177/0300060517715340. Epub 2017 Jul 6.
Objective To investigate the underlying functional network brain-activity changes in patients with adult comitant exotropia strabismus (CES) and the relationship with clinical features using the voxel-wise degree centrality (DC) method. Methods A total of 30 patients with CES (17 men, 13 women), and 30 healthy controls (HCs; 17 men, 13 women) matched in age, sex, and education level participated in the study. DC was used to evaluate spontaneous brain activity. Receiver operating characteristic (ROC) curve analysis was conducted to distinguish CESs from HCs. The relationship between mean DC values in various brain regions and behavioral performance was examined with correlation analysis. Results Compared with HCs, CES patients exhibited decreased DC values in the right cerebellum posterior lobe, right inferior frontal gyrus, right middle frontal gyrus and right superior parietal lobule/primary somatosensory cortex (S1), and increased DC values in the right superior temporal gyrus, bilateral anterior cingulate, right superior temporal gyrus, and left inferior parietal lobule. However, there was no correlation between mean DC values and behavioral performance in any brain regions. Conclusions Adult comitant exotropia strabismus is associated with abnormal brain network activity in various brain regions, possibly reflecting the pathological mechanisms of ocular motility disorders in CES.
目的 采用基于体素的度中心性（DC）方法，研究成人共同性外斜视（CES）患者潜在的功能网络脑活动变化及其与临床特征的关系。方法 共有30例CES患者（男17例，女13例）和30名健康对照者（HCs；男17例，女13例）参与研究，两组在年龄、性别和教育水平上相匹配。采用DC评估自发脑活动。进行受试者工作特征（ROC）曲线分析以区分CES患者和HCs。通过相关性分析检验各脑区平均DC值与行为表现之间的关系。结果 与HCs相比，CES患者右侧小脑后叶、右侧额下回、右侧额中回和右侧顶上小叶/初级躯体感觉皮层（S1）的DC值降低，而右侧颞上回、双侧前扣带回、右侧颞上回和左侧顶下小叶的DC值升高。然而，各脑区的平均DC值与行为表现之间均无相关性。结论 成人共同性外斜视与多个脑区的异常脑网络活动有关，可能反映了CES中眼球运动障碍的病理机制。
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