Maseb'a Mwang Sulu Stanislas, Batalansi Donatien Babaka, Sulu Arnold Maseb Sul, Mukuku Olivier, Mboloko Justin Esimo, Mashinda Désiré Kulimba, Massamba Bienvenu Lebwaze, Tshimpi Antoine Wola
Nganda Hospital Center, Kinshasa, Democratic Republic of the Congo.
Kinshasa Provincial General Reference Hospital, Kinshasa, Democratic Republic of the Congo.
Int J Breast Cancer. 2022 Aug 5;2022:8860947. doi: 10.1155/2022/8860947. eCollection 2022.
The molecular classification of breast cancer (BC) based on gene expression and then protein profile has made it possible to distinguish different molecular subtypes. The objective of this study was to describe immunohistochemical features of BC infiltrating women at the Nganda Hospital Center in Kinshasa, Democratic Republic of the Congo (DRC).
A retrospective study from 2014 to 2019 involved 190 patients with invasive BC who were enrolled at the Nganda Hospital Center. The tumors were analyzed histologically and classified after an immunohistochemical study into subtypes: luminal A, luminal B, HER2-overexpressed, and triple-negative. A chi-square test was performed to assess the relationship between age, histological grade, and these subtypes.
The luminal A subtype (44.74%) was the most common, followed by luminal B (40.53%), triple-negative (10.53%), and HER2-overexpressed (4.20%). The mean age of the patients at diagnosis was 48.27 years. Of all cases, 94.21% were ductal, 2.63% were mucinous, and 2.11% were lobular. They were classified as grade I in 68.82% of the cases, grade II in 28.42% of the cases, and grade III in 3.16% of the cases. There was a significant association between histological grade and breast cancer subtypes ( < 0.0001), but no correlation was found with age ( = 0.467).
In our BC patients, the luminal A was predominant, while HER2-overexpressed was the least found. A strong association was noted between histological grade and molecular subtypes. These results should allow for important clinical and policy implications for BC control in the DRC.
基于基因表达及随后的蛋白质谱对乳腺癌（BC）进行分子分类，使得区分不同分子亚型成为可能。本研究的目的是描述在刚果民主共和国（DRC）金沙萨的恩甘达医院中心浸润性乳腺癌女性患者的免疫组化特征。
一项2014年至2019年的回顾性研究纳入了恩甘达医院中心的190例浸润性乳腺癌患者。对肿瘤进行组织学分析，并在免疫组化研究后将其分为以下亚型：腔面A型、腔面B型、HER2过表达型和三阴性型。采用卡方检验评估年龄、组织学分级与这些亚型之间的关系。
腔面A型（44.74%）最为常见，其次是腔面B型（40.53%）、三阴性型（10.53%）和HER2过表达型（4.20%）。患者诊断时的平均年龄为48.27岁。在所有病例中，94.21%为导管癌，2.63%为黏液癌，2.11%为小叶癌。68.82%的病例被分类为I级，28.42%的病例为II级，3.16%的病例为III级。组织学分级与乳腺癌亚型之间存在显著关联（<0.0001），但与年龄无相关性（=0.467）。
在我们的乳腺癌患者中，腔面A型占主导，而HER2过表达型最少见。组织学分级与分子亚型之间存在密切关联。这些结果应为刚果民主共和国乳腺癌控制提供重要的临床和政策启示。
