Villa Nicole, Badla Omar, Goit Raman, Saddik Samia E, Dawood Sarah N, Rabih Ahmad M, Mohammed Ahmad, Raman Aishwarya, Uprety Manish, Calero Maria Jose, Villanueva Maria Resah B, Joshaghani Narges, Mohammed Lubna
Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
General Surgery, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Cureus. 2022 Jul 11;14(7):e26751. doi: 10.7759/cureus.26751. eCollection 2022 Jul.
Systemic lupus erythematosus (SLE) is a chronic inflammatory connective tissue disease with varying clinical manifestations. Recent studies have proposed that leptin may be related to SLE development. This study aims to assess current information regarding the relationship between leptin and SLE. A systematic search was done using PubMed, Google Scholar, ScienceDirect, Epistemonikos, and Cochrane Library databases. Studies published in the English language in the last 10 years were selected based on predefined eligibility criteria. The quality of the studies was evaluated using the Newcastle-Ottawa Scale and the Assessment of Multiple Systematic Reviews 2 tool. A total of 12 studies were included in this systematic review. These included systematic reviews/meta-analyses, cross-sectional studies, and case-control studies Based on the findings of this review, we conclude thatleptin is significantly elevated in SLE patients; however, it does not seem to correlate with disease activity. The exact mechanism of leptin in the pathogenesis of the disease remains unknown and further research is needed regarding this aspect.
系统性红斑狼疮（SLE）是一种临床表现多样的慢性炎症性结缔组织病。最近的研究表明，瘦素可能与SLE的发生有关。本研究旨在评估有关瘦素与SLE之间关系的现有信息。我们使用PubMed、谷歌学术、ScienceDirect、Epistemonikos和Cochrane图书馆数据库进行了系统检索。根据预先设定的纳入标准，选取了过去10年发表的英文研究。使用纽卡斯尔-渥太华量表和多重系统评价2工具对研究质量进行评估。本系统评价共纳入12项研究。这些研究包括系统评价/荟萃分析、横断面研究和病例对照研究。基于本评价的结果，我们得出结论：SLE患者的瘦素水平显著升高；然而，它似乎与疾病活动度无关。瘦素在该疾病发病机制中的具体机制尚不清楚，这方面需要进一步研究。
