Department of Immunology, College of Basic Medical Science, Dalian Medical University, Dalian, China.
Department of Immunology, College of Basic Medical Science, Dalian Medical University, Dalian; Department of Clinical Laboratory, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Clin Exp Rheumatol. 2020 Nov-Dec;38(6):1238-1246. Epub 2020 Jun 30.
Initial studies investigating peripheral levels of leptin and soluble leptin receptor (LepR) in systemic lupus erythematosus (SLE) patients have generated a number of controversial results. Thus, we conducted a meta-analysis to evaluate the circulating leptin level, soluble LepR level and related gene polymorphism in SLE patients.
We performed a meta-analysis comparing the circulating leptin level, LepR level and their gene polymorphism in patients with SLE to controls, and evaluate the relationship between leptin levels, LepR levels and SLE disease activity. Pubmed, Embase, Cochrane, CNKI, WanFang and VIP databases were searched systematically with no restriction to languages and years (up to Feb. 2020). Stata v. 14.0 was used to calculate statistical data.
34 articles involving 7337 SLE patients and 6866 healthy controls were included in this meta-analysis. Compared with the controls, SLE patients had a significantly higher level of leptin, in particular for active SLE patients, regardless of sample size, source, or assay method. The elevated leptin level was only found in the female SLE group, but not in the male SLE group. Apart from the South American subgroup, other ethnicity subgroups showed significantly higher levels of leptin in SLE patients. A marginally lower level of LepR in SLE patients was also observed. The LepR gene rs1137101 variant (i.e. AG+GG) was borderline significantly associated with the increased risk of SLE.
Our meta-analysis revealed thta SLE patients had an elevated leptin level and decreased LepR level. LepR gene rs1137101 mutation might be associated with increased susceptibility to SLE.
最初的研究调查了系统性红斑狼疮（SLE）患者外周血瘦素和可溶性瘦素受体（LepR）水平，得出了一些有争议的结果。因此，我们进行了一项荟萃分析，以评估 SLE 患者的循环瘦素水平、可溶性 LepR 水平及其相关基因多态性。
我们进行了一项荟萃分析，比较了 SLE 患者与对照组的循环瘦素水平、LepR 水平及其基因多态性，并评估了瘦素水平、LepR 水平与 SLE 疾病活动度的关系。系统检索了 Pubmed、Embase、Cochrane、CNKI、万方和 VIP 数据库，不限制语言和年份（截至 2020 年 2 月）。使用 Stata v. 14.0 计算统计数据。
本荟萃分析纳入了 34 篇文章，共涉及 7337 例 SLE 患者和 6866 例健康对照者。与对照组相比，SLE 患者的瘦素水平明显升高，尤其是活动期 SLE 患者，无论样本量、来源或检测方法如何。仅在女性 SLE 组中发现瘦素水平升高，而在男性 SLE 组中未发现。除了南美洲亚组外，其他种族亚组的 SLE 患者瘦素水平明显升高。SLE 患者的 LepR 水平也略有降低。LepR 基因 rs1137101 变体（即 AG+GG）与 SLE 的发病风险增加呈边缘显著相关。
本荟萃分析表明，SLE 患者存在瘦素水平升高和 LepR 水平降低。LepR 基因 rs1137101 突变可能与 SLE 的易感性增加有关。
