Metabolism of hexachlorobenzene by rat-liver microsomes.
作者信息
Stewart F P, Smith A G
出版信息
IARC Sci Publ. 1986(77):325-7.
PMID:3596722
Abstract
Hexachlorobenzene (HCB) was metabolized to dechlorinated and hydroxylated products by the mixed-function oxidase system of rat-liver microsomes (phenobarbital- or 3-methylcholanthrene-induced). Metabolites were identified by gas-liquid chromatography-mass spectrometry. 14C-HCB was bound to microsomal protein. No explanation was found for the sex-dependent hepatotoxicity of HCB in rats.
摘要
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