Department of Hematology, Tianjin Medical University General Hospital, Tianjin, China.
Front Immunol. 2022 Jul 28;13:936967. doi: 10.3389/fimmu.2022.936967. eCollection 2022.
Pyruvate kinase (PK) is a key enzyme that catalyzes the dephosphorylation of phosphoenolpyruvate (PEP) into pyruvate, and is responsible for the production of ATP during glycolysis. As another important isozyme of PK, pyruvate kinase M2 (PKM2) exists in cells with high levels of nucleic acid synthesis, such as normal proliferating cells (e.g., lymphocytes and intestinal epithelial cells), embryonic cells, adult stem cells, and tumor cells. With further research, PKM2, as an important regulator of cellular pathophysiological activity, has attracted increasing attention in the process of autoimmune response and inflammatory. In this re]view, we examine the contribution of PKM2 to the human immune response. Further studies on the immune mechanisms of PKM2 are expected to provide more new ideas and drug targets for immunotherapy of inflammatory and autoimmune diseases, guiding drug development and disease treatment.
丙酮酸激酶（PK）是一种关键酶，可催化磷酸烯醇丙酮酸（PEP）去磷酸化生成丙酮酸，在糖酵解过程中负责产生 ATP。作为 PK 的另一种重要同工酶，丙酮酸激酶 M2（PKM2）存在于核酸合成水平较高的细胞中，如正常增殖细胞（如淋巴细胞和肠上皮细胞）、胚胎细胞、成体干细胞和肿瘤细胞。随着进一步的研究，PKM2 作为细胞病理生理活动的重要调节剂，在自身免疫反应和炎症过程中引起了越来越多的关注。在这篇综述中，我们研究了 PKM2 对人类免疫反应的贡献。进一步研究 PKM2 的免疫机制有望为炎症性和自身免疫性疾病的免疫治疗提供更多新的思路和药物靶点，指导药物开发和疾病治疗。
