Kondratyeva Elena I, Odinaeva Nuriniso D, Klimov Leonid Ya, Podchernyaeva Nadeshda S, Ilenkova Natalya I, Dolbnya Svetlana V, Zhekaite Elena K, Kuryaninova Victoria A, Kotova Yuliya V, Tikhaya Margarita I, Shitkovskaya Elena P, Bychina Liubov V, Drepa Tamara G, Zodbinova Aisa E, Melyanovskaya Yuliya L, Petrova Nika V, Loshkova Elena V, Kutsev Sergei I
Research Centre for Medical Genetics, Moscow, Russia.
Research Clinical Institute for Childhood of the Moscow Region, Moscow, Russia.
Front Pediatr. 2022 Jul 26;10:915943. doi: 10.3389/fped.2022.915943. eCollection 2022.
Juvenile idiopathic arthritis (JIA) is a chronic autoimmune disease characterized by destructive and inflammatory damage to the joints. The aim in this study was to compare vitamin D levels between children and adolescents, 1-18 years of age, with juvenile idiopathic arthritis (JIA) and a health control group of peers. We considered effects of endogenous, exogenous, and genetic factors on measured differences in vitamin D levels among children with JIA.
Our findings are based on a study sample of 150 patients with various variants of JIA and 277 healthy children. The blood level of vitamin D was assessed by calcidiol level. The following factors were included in our analysis: age and sex; level of insolation in three regions of country (center, south, north); assessment of dietary intake of vitamin D; effect of prophylactic doses of cholecalciferol; a relationship between the TaqI, FokI, and BsmI polymorphisms of the gene and serum 25(OH)D concentration.
We identified a high frequency of low vitamin D among children with JIA, prevalence of 66%, with the medial level of vitamin D being within the range of "insufficient" vitamin D. We also show that the dietary intake of vitamin D by children with JIA is well below expected norms, and that prophylactic doses of vitamin D supplementation (cholecalciferol) at a dose of 500-1,000 IU/day and 1,500-2,000 IU/day do not meet the vitamin D needs of children with JIA. Of importance, we show that vitamin D levels among children with JIA are not affected by clinical therapies to manage the disease nor by the present of VDR genetic variants.
Prophylactic administration of cholecalciferol and season of year play a determining role in the development of vitamin D deficiency and insufficiency.
幼年特发性关节炎（JIA）是一种慢性自身免疫性疾病，其特征是关节出现破坏性和炎症性损伤。本研究的目的是比较1至18岁患幼年特发性关节炎（JIA）的儿童和青少年与同龄健康对照组之间的维生素D水平。我们考虑了内源性、外源性和遗传因素对JIA患儿维生素D水平测量差异的影响。
我们的研究结果基于150例患有各种JIA变体的患者和277名健康儿童的样本。通过骨化二醇水平评估维生素D的血液水平。我们的分析包括以下因素：年龄和性别；该国三个地区（中部、南部、北部）的日照水平；维生素D饮食摄入量评估；胆钙化醇预防剂量的影响；基因的TaqI、FokI和BsmI多态性与血清25(OH)D浓度之间的关系。
我们发现JIA患儿中维生素D水平低的频率很高，患病率为66%，维生素D的中位数水平处于“不足”范围内。我们还表明，JIA患儿的维生素D饮食摄入量远低于预期标准，每天500 - 1000 IU和1500 - 2000 IU的维生素D补充预防剂量（胆钙化醇）不能满足JIA患儿对维生素D的需求。重要的是，我们表明JIA患儿的维生素D水平不受治疗该疾病的临床疗法或VDR基因变体存在的影响。
胆钙化醇的预防性给药和一年中的季节在维生素D缺乏和不足的发生中起决定性作用。
