Department of Clinical Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Molecular Medicine Research Center,Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Clin Rheumatol. 2020 Dec;39(12):3555-3569. doi: 10.1007/s10067-020-05143-y. Epub 2020 May 22.
Vitamin D is involved in immune system modulation as well as in calcium and bone homeostasis, hence plays a role in rheumatoid arthritis (RA) etiopathogenesis. A bulk of studies in different populations have assessed the association between the vitamin D receptor (VDR) gene polymorphisms and the risk of RA, reporting conflicting results. Therefore, we designed a meta-analysis to comprehensively evaluate the association of VDR gene polymorphisms and RA risk. All potential studies reporting the association between VDR gene polymorphisms and susceptibility to RA published till February 2020 were retrieved through systematic search of database, including Scopus and MEDLINE. Strength of pooled association was determined through calculating the pooled odds ratios (ORs) and 95% confidence intervals (CIs). Subgroup analysis was performed by stratifying the studies by population type. This meta-analysis included 23 eligible studies (21 articles) overall. We noticed that FokI SNP had a significant protective association with susceptibility to RA in the overall analysis as well as in Europeans and Asians. TaqI SNP decreased the RA risk in Africans and Arabs, but not in the overall analysis. Likewise, BsmI SNP and RA risk in the overall population analysis was not significant. Interestingly, BsmI polymorphism increased RA risk in Africans. This meta-analysis offers a significant association between VDR gene polymorphism and susceptibility to RA in both overall and ethnic-specific analysis. However, different polymorphisms acted inversely in increasing or decreasing RA risk in different populations.
维生素 D 参与免疫系统的调节以及钙和骨骼的动态平衡，因此在类风湿关节炎 (RA) 的发病机制中发挥作用。大量的研究在不同人群中评估了维生素 D 受体 (VDR) 基因多态性与 RA 风险之间的关联，报告的结果相互矛盾。因此，我们设计了一项荟萃分析来全面评估 VDR 基因多态性与 RA 风险的关联。通过系统搜索数据库（包括 Scopus 和 MEDLINE），检索了截至 2020 年 2 月报道 VDR 基因多态性与 RA 易感性之间关联的所有潜在研究。通过计算合并优势比 (OR) 和 95%置信区间 (CI) 来确定合并关联的强度。通过按人群类型分层研究进行亚组分析。这项荟萃分析共包括 23 项符合条件的研究（21 篇文章）。我们注意到 FokI SNP 在总体分析以及欧洲人和亚洲人中与 RA 的易感性有显著的保护关联。TaqI SNP 降低了非洲人和阿拉伯人患 RA 的风险，但在总体分析中并非如此。同样，BsmI SNP 与总体人群分析中的 RA 风险无显著相关性。有趣的是，BsmI 多态性增加了非洲人患 RA 的风险。这项荟萃分析表明 VDR 基因多态性与 RA 的易感性在总体和种族特异性分析中均存在显著关联。然而，不同的多态性在不同人群中以增加或减少 RA 风险的相反方式起作用。
