HIV-1 阳性男男性行为者丙型肝炎再感染率：系统评价和荟萃分析。

Reinfection rate of hepatitis C in HIV-1 positive men who have sex with men: A systematic review and meta-analysis.

机构信息

Department of Health Management Center and Institute of Health Management, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

Department of Molecular Biology and Biotechnology, School of Biological Sciences, College of Agriculture and Natural Sciences, University of Cape Coast, Cape Coast, Ghana.

出版信息

Front Public Health. 2022 Jul 29;10:855989. doi: 10.3389/fpubh.2022.855989. eCollection 2022.

DOI:10.3389/fpubh.2022.855989

PMID:35968434

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9372531/

Abstract

PURPOSE

A reduction of 80% in new Hepatitis C virus (HCV) infection is expected by 2030. However, high HCV reinfection rates have been reported among the high-risk population. This meta-analysis aimed to assess the HCV reinfection rate after successful treatment of HIV-1 coinfected MSM populations.

METHODS

Bibliographic databases were searched and a random-effect model was utilized to calculate the pooled HCV reinfection rate. Sub-group and meta-regression were used to explore heterogeneity among selected studies. A funnel plot and Egger's regression test were performed to estimate the publication bias.

RESULTS

Sixteen studies with 9,017.2 person-years (PY) follow-up were included. The overall HCV reinfection rate following successful treatment among HIV-1-infected MSM was 5.27/100 PY (95% CI, 3.98, 6.96). Lower reinfection rates were observed in developed parts of Europe (5.28/100 PY; 95% CI, 3.73, 6.84) and North America (3.92/100 PY; 95% CI, 1.67, 6.17). Reinfection rates among people with HCV test intervals of fewer than 6 months (7.59/100 PY; 95% CI: 5.15, 10.03) were significantly higher than those with more than 6 months test interval (2.88/100 PY; 95% CI: 2.26, 3.50), with an adjusted RR of 1.86 (95% CI, 1.06, 3.13). The adjusted study factors explained 91.03% the of studies' heterogeneity.

CONCLUSION

HCV reinfection rate was high in successfully treated MSM who were coinfected with HIV-1. A shorter HCV test interval may help to explore more HCV reinfections. HCV reinfection rate studies from HIV-1 coinfected MSM in underdeveloped countries are urgently needed.

META REGISTRATION

PROSPERO: CRD42021285206, URL: https://www.crd.york.ac.uk/prospero/.

摘要

目的

预计到 2030 年，新的丙型肝炎病毒（HCV）感染将减少 80%。然而，高危人群的 HCV 再感染率报告较高。本荟萃分析旨在评估成功治疗 HIV-1 合并感染的男男性行为者（MSM）人群后的 HCV 再感染率。

方法

检索文献数据库，并采用随机效应模型计算 HCV 再感染率的合并率。采用亚组和元回归分析来探索选定研究中的异质性。绘制漏斗图和 Egger 回归检验来评估发表偏倚。

结果

纳入了 16 项研究，随访时间为 9017.2 人年（PY）。HIV-1 感染的 MSM 经成功治疗后，HCV 的总体再感染率为 5.27/100PY（95%CI，3.98，6.96）。在欧洲发达地区（5.28/100PY；95%CI，3.73，6.84）和北美（3.92/100PY；95%CI，1.67，6.17），再感染率较低。HCV 检测间隔少于 6 个月的人群的再感染率（7.59/100PY；95%CI：5.15，10.03）明显高于检测间隔超过 6 个月的人群（2.88/100PY；95%CI：2.26，3.50），调整后的 RR 为 1.86（95%CI，1.06，3.13）。调整后的研究因素解释了 91.03%的研究异质性。