Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.
Tianjin Social Science Laboratory of Students' Mental Development and Learning, Academy of Psychology and Behavior, Tianjin Normal University, Tianjin, China.
Front Public Health. 2022 Jul 29;10:929909. doi: 10.3389/fpubh.2022.929909. eCollection 2022.
Investigate the anxiety and depression states among dry eye (DE) patients during the COVID-19 outbreak and analyze their influence factors.
The study was conducted in a tertiary eye hospital in Tianjin, China from March-April 2021. Four hundred twenty-eight DE patients were tested with the Ocular Surface Disease Index, Short Healthy Anxiety Inventory, Hospital Anxiety and Depression Scale, and Pittsburgh Sleep Quality Index. Descriptive statistics was used to assess the difference between DE with depression or anxiety among different groups. And multiple linear regression was used to explore factors that influence anxiety and depression in DE patients.
The incidence rates of anxiety and depression among DE patients during COVID-19 were 27.34 and 26.87%, respectively. The proportion with comorbid anxiety and depression was 24.30%. Patients' education level ( = -3.001, < 0.05; = -3.631, < 0.05), course of disease ( = 2.341, < 0.05; = 2.444, < 0.05), health anxiety ( = 3.015, < 0.05; = 2.731, < 0.05), and subjective sleep quality ( = 3.610, < 0.05; = 4.203, < 0.05) had certain influences on anxiety and depression.
The results showed that subjective symptoms of DE patients were related to depression and anxiety. Higher education, shorter disease duration, lower health anxiety levels, and better subjective sleep quality were associated with the reduced depressive and anxiety symptoms in DE patients. These findings could be deemed beneficial to the treatment and prevention of DE during the COVID-19 epidemic.
调查 COVID-19 期间干眼症（DE）患者的焦虑和抑郁状态，并分析其影响因素。
本研究于 2021 年 3 月至 4 月在中国天津的一家三级眼科医院进行。对 428 例 DE 患者进行了眼表疾病指数、短健康焦虑量表、医院焦虑抑郁量表和匹兹堡睡眠质量指数测试。采用描述性统计分析评估不同组别中 DE 伴发抑郁或焦虑的差异。采用多元线性回归分析探讨影响 DE 患者焦虑和抑郁的因素。
COVID-19 期间 DE 患者的焦虑和抑郁发生率分别为 27.34%和 26.87%。共病焦虑和抑郁的比例为 24.30%。患者的教育水平（ = -3.001， < 0.05； = -3.631， < 0.05）、病程（ = 2.341， < 0.05； = 2.444， < 0.05）、健康焦虑（ = 3.015， < 0.05； = 2.731， < 0.05）和主观睡眠质量（ = 3.610， < 0.05； = 4.203， < 0.05）对焦虑和抑郁有一定影响。
结果表明，DE 患者的主观症状与抑郁和焦虑有关。较高的教育程度、较短的病程、较低的健康焦虑水平和更好的主观睡眠质量与 DE 患者抑郁和焦虑症状的减轻相关。这些发现可能有助于 COVID-19 流行期间 DE 的治疗和预防。
