School of Chemistry, University of Hyderabad, Hyderabad, Telangana 500046, India.
Chem Commun (Camb). 2022 Aug 30;58(70):9778-9781. doi: 10.1039/d2cc03730k.
A metal-free approach to construct indole rings from vinylogous amides derived from -alkynylanilines involving a cyclization, retro-aza-Michael reaction and amine trapping cascade is reported here. This atom-economical transformation has been extended to synthesize benzofuran derivatives using analogous vinylogous esters derived from -alkynylphenols. The excellent stereochemical outcome of the double bond geometry in the products makes it attractive.
本文报道了一种无金属方法，通过 -炔基苯胺衍生的乙烯基酰胺的环化、反氮杂-Michael 反应和胺捕获级联反应来构建吲哚环。这种原子经济性转化已扩展到使用类似的 -炔基苯酚衍生的乙烯基酯来合成苯并呋喃衍生物。产物中双键几何形状的优异立体化学结果使其具有吸引力。
