Departments of Geriatrics.
Neurology, Tergooi Hospital, Blaricum, The Netherlands.
Alzheimer Dis Assoc Disord. 2022;36(4):335-339. doi: 10.1097/WAD.0000000000000523. Epub 2022 Aug 15.
The aim of this study is to investigate the association between basal ganglia calcification (BGC) and depressive symptoms within older adults with mild cognitive impairment (MCI) or dementia.
For this cross-sectional study, we included patients with MCI or dementia who visited the memory clinic between April 2009 and April 2015. All patients underwent a standard diagnostic workup, including assessment of depressive symptoms with the Geriatric Depression Scale and computed tomography imaging of the brain. Computed tomography scans were assessed for presence and severity of BGC. To analyse the association between BGC and depressive symptoms, binary logistic regression models were performed with adjustment for age, sex, cardiovascular risk factors, and cardiovascular diseases.
In total, 1054 patients were included (median age: 81.0 y; 39% male). BGC was present in 44% of the patients, of which 20% was classified as mild, 20% as moderate, and 4% as severe. There were 223 patients (21%) who had a Geriatric Depression Scale score indicative of depressive symptoms. No association was found between the presence or severity of BGC and depressive symptoms.
Although both BGC and depressive symptoms were common in patients with MCI or dementia, no association was demonstrated between the presence or severity of BGC and depressive symptoms.
本研究旨在探讨老年轻度认知障碍（MCI）或痴呆患者基底节钙化（BGC）与抑郁症状之间的关系。
本横断面研究纳入了 2009 年 4 月至 2015 年 4 月期间在记忆诊所就诊的 MCI 或痴呆患者。所有患者均接受了标准诊断评估，包括使用老年抑郁量表评估抑郁症状和大脑计算机断层扫描成像。对计算机断层扫描进行评估以确定 BGC 的存在和严重程度。为了分析 BGC 与抑郁症状之间的关系，我们采用二元逻辑回归模型进行分析，并对年龄、性别、心血管危险因素和心血管疾病进行了调整。
共纳入 1054 例患者（中位年龄：81.0 岁；39%为男性）。44%的患者存在 BGC，其中 20%为轻度、20%为中度、4%为重度。223 例（21%）患者的老年抑郁量表评分提示存在抑郁症状。BGC 的存在或严重程度与抑郁症状之间无相关性。
尽管 MCI 或痴呆患者中 BGC 和抑郁症状都很常见，但 BGC 的存在或严重程度与抑郁症状之间无相关性。
