基底节钙化：与认知功能无关。

Basal ganglia calcifications: No association with cognitive function.

机构信息

University Medical Center Utrecht, Utrecht University, Department of Geriatrics, Utrecht, the Netherlands; Tergooi Medical Center, Department of Geriatrics, Blaricum, the Netherlands.

出版信息

J Neuroradiol. 2023 Mar;50(2):266-270. doi: 10.1016/j.neurad.2022.02.001. Epub 2022 Feb 5.

DOI:10.1016/j.neurad.2022.02.001

PMID:35134441

Abstract

BACKGROUND AND PURPOSE

Basal ganglia calcifications (BGC), a form of vascular calcification, are a common brain computed tomography (CT) finding. We investigated whether BGC are associated with cognitive function and examined the association between vascular risk factors and BGC.

MATERIAL AND METHODS

Patients who visited a memory clinic of a Dutch general hospital between April 2009 and April 2015 were included. The patients underwent a standard diagnostic work up including cognitive tests (Cambridge Cognitive Examination, including the Mini Mental State Examination) and brain CT. Vascular risk factors such as hypertension, diabetes mellitus, hyperlipidemia and smoking were assessed. CTs were analyzed for presence and severity (absent, mild, moderate or severe) of BGC. Multivariable logistic regression was used to identify risk factors for BGC and linear regression for the association between BGC and cognitive function.

RESULTS

Of the 1992 patients, 40.3% was male. The median age was 80 years and 866 patients (43.5%) had BGC. BGC was associated with female gender (odds ratio (OR) 1.27, 95% confidence interval (CI) 1.06-1.53, p 0.011), and inversely associated with hypertension (OR 0.74, 95% CI 0.60-0.89, p 0.002) and use of antihypertensive drugs (OR 0.79, 95% CI 0.64-0.98, p 0.031). No association was found between presence and severity of BGC and cognitive function or other vascular risk factors.

CONCLUSIONS

No association with cognitive function was found. Risk factors for BGC were female gender, while hypertension and antihypertensive drug use were associated with a lower risk of BGC.

摘要

背景与目的

基底节钙化（BGC）是一种血管钙化形式，是常见的脑计算机断层扫描（CT）发现。我们研究了 BGC 是否与认知功能相关，并检查了血管危险因素与 BGC 之间的关联。

材料与方法

纳入 2009 年 4 月至 2015 年 4 月期间在荷兰一家综合医院记忆诊所就诊的患者。患者接受了标准的诊断检查，包括认知测试（剑桥认知测试，包括简易精神状态检查）和脑 CT。评估了血管危险因素，如高血压、糖尿病、高脂血症和吸烟。对 CT 进行分析以确定 BGC 的存在和严重程度（无、轻度、中度或重度）。使用多变量逻辑回归来确定 BGC 的危险因素，使用线性回归来确定 BGC 与认知功能之间的关联。

结果

在 1992 名患者中，40.3%为男性。中位年龄为 80 岁，866 名患者（43.5%）存在 BGC。BGC 与女性性别相关（优势比（OR）1.27，95%置信区间（CI）1.06-1.53，p 0.011），与高血压（OR 0.74，95% CI 0.60-0.89，p 0.002）和使用抗高血压药物呈负相关（OR 0.79，95% CI 0.64-0.98，p 0.031）。BGC 的存在和严重程度与认知功能或其他血管危险因素之间没有关联。