Health Sciences Postgraduate Program, Health Sciences Center, State University of Londrina (UEL), Londrina, Paraná, Brazil.
Health Sciences Postgraduate Program, Health Sciences Center, State University of Londrina (UEL), Londrina, Paraná, Brazil; Department of Statistics, Center of Exact Sciences, State University of Londrina, (UEL), Londrina, Paraná, Brazil.
J Psychiatr Res. 2022 Nov;155:1-9. doi: 10.1016/j.jpsychires.2022.07.052. Epub 2022 Jul 31.
Elevated C-reactive protein (CRP) levels were associated with cognitive decline, sedentary behaviour, and childhood trauma in patients with major affective disorders. This study aims to examine the association of peripheral CRP levels, cognitive function, childhood trauma, sedentary behaviour, and quality of life in individuals with major affective disorders, including bipolar disorder (BD), major depressive disorder (MDD), and individuals without mood disorders (controls). We included outpatients with BD (n = 42), MDD (n = 27), and healthy controls (n = 40). All participants were assessed by a questionnaire, structured clinical interview, and the following scales: international physical activity questionnaire, childhood trauma questionnaire, 17-item Hamilton Depression Rating Scale (HDRS), and World Health Organization Quality of Life instrument, brief version (WHOQOL-BREF). Other measures were included: hs-CRP levels, anthropometric measures, and cognitive tests (Trail-making test part A and part B, Stroop test, phonemic verbal fluency test, and semantic verbal fluency test). Our results indicated that BD outpatients were less significantly physically active on leisure domain than controls. Levels of hs-CRP ≥ 5 mg/L were significantly linked with a history of childhood sexual abuse and childhood physical abuse, as well as worse neurocognitive performance in major depressive disorders, mainly in BD. There was a significant negative correlation between Trail-making part B score and WHOQOL-BREF total score. The findings support the hypothesis that levels of hs-CRP ≥ 5 mg/L may be a possible predictor of cognitive dysfunction, childhood sexual abuse and sedentary behaviour in major affective disorders.
C 反应蛋白（CRP）水平升高与重性情感障碍患者的认知功能下降、久坐行为和儿童期创伤有关。本研究旨在探讨重性情感障碍患者（包括双相情感障碍（BD）、重性抑郁障碍（MDD）和无心境障碍的个体）外周血 CRP 水平、认知功能、儿童期创伤、久坐行为和生活质量之间的关系。我们纳入了 42 名 BD 门诊患者、27 名 MDD 患者和 40 名健康对照者。所有参与者均通过问卷调查、结构化临床访谈和以下量表进行评估：国际体力活动问卷、儿童期创伤问卷、汉密尔顿抑郁评定量表（HDRS）17 项版和世界卫生组织生活质量量表，简短版（WHOQOL-BREF）。其他测量包括：hs-CRP 水平、人体测量指标和认知测试（连线测试 A 和 B、Stroop 测试、音位流畅性测试和语义流畅性测试）。我们的研究结果表明，BD 门诊患者在休闲领域的身体活动量明显低于对照组。hs-CRP≥5mg/L 与儿童期性虐待和儿童期身体虐待史以及重性抑郁障碍患者的神经认知功能下降显著相关，主要是在 BD 中。连线测试 B 部分得分与 WHOQOL-BREF 总分呈显著负相关。这些发现支持了 hs-CRP≥5mg/L 可能是重性情感障碍患者认知功能障碍、儿童期性虐待和久坐行为的一个潜在预测因子的假设。
