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Autologous haematopoietic stem-cell transplantation versus bortezomib-melphalan-prednisone, with or without bortezomib-lenalidomide-dexamethasone consolidation therapy, and lenalidomide maintenance for newly diagnosed multiple myeloma (EMN02/HO95): a multicentre, randomised, open-label, phase 3 study.自体造血干细胞移植对比硼替佐米-美法仑-泼尼松（联合或不联合硼替佐米-来那度胺-地塞米松巩固治疗）以及来那度胺维持治疗用于新诊断的多发性骨髓瘤（EMN02/HO95）：一项多中心、随机、开放标签的3期研究
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Daratumumab, lenalidomide, bortezomib, and dexamethasone for transplant-eligible newly diagnosed multiple myeloma: the GRIFFIN trial.达雷妥尤单抗、来那度胺、硼替佐米和地塞米松用于适合移植的新诊断多发性骨髓瘤：GRIFFIN 试验。
Blood. 2020 Aug 20;136(8):936-945. doi: 10.1182/blood.2020005288.
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Bortezomib, lenalidomide, and dexamethasone as induction therapy prior to autologous transplant in multiple myeloma.硼替佐米、来那度胺和地塞米松作为多发性骨髓瘤自体移植前的诱导治疗。
Blood. 2019 Oct 17;134(16):1337-1345. doi: 10.1182/blood.2019000241.
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Bortezomib, thalidomide, and dexamethasone with or without daratumumab before and after autologous stem-cell transplantation for newly diagnosed multiple myeloma (CASSIOPEIA): a randomised, open-label, phase 3 study.硼替佐米、沙利度胺和地塞米松联合或不联合达雷妥尤单抗用于新诊断多发性骨髓瘤患者自体造血干细胞移植前后（CASSIOPEIA）：一项随机、开放标签、3 期研究。
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Conditioning with busulfan plus melphalan versus melphalan alone before autologous haemopoietic cell transplantation for multiple myeloma: an open-label, randomised, phase 3 trial.在多发性骨髓瘤自体造血细胞移植前，白消安加美法仑与单用美法仑进行预处理的比较：一项开放标签、随机、3期试验。
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Intravenous busulfan plus melphalan versus melphalan alone as conditioning regimen for patients with multiple myeloma.静脉注射白消安加美法仑与单独使用美法仑作为多发性骨髓瘤患者的预处理方案比较。
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Efficacy and safety of autologous stem cell transplantation in patients aged ≥ 65 years with multiple myeloma in the era of novel agents.新型药物时代≥65岁多发性骨髓瘤患者自体干细胞移植的疗效与安全性
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Phase 3 study of subcutaneous bortezomib, thalidomide, and prednisolone consolidation after subcutaneous bortezomib-based induction and autologous stem cell transplantation in patients with previously untreated multiple myeloma: the VCAT study.初治多发性骨髓瘤患者皮下硼替佐米为基础诱导及自体干细胞移植后皮下硼替佐米、沙利度胺和泼尼松巩固的 3 期研究：VCAT 研究。
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Autologous Transplantation, Consolidation, and Maintenance Therapy in Multiple Myeloma: Results of the BMT CTN 0702 Trial.自体移植、巩固和维持治疗多发性骨髓瘤：BMT CTN 0702 试验结果。
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Lenalidomide maintenance versus observation for patients with newly diagnosed multiple myeloma (Myeloma XI): a multicentre, open-label, randomised, phase 3 trial.来那度胺维持治疗与观察用于初诊多发性骨髓瘤患者（Myeloma XI）：一项多中心、开放标签、随机、3 期临床试验。
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Guidelines on the diagnosis and management of multiple myeloma treatment: Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular Project guidelines: Associação Médica Brasileira - 2022. Part I.

作者信息

Maiolino Angelo, Crusoé Edvan de Queiroz, Martinez Gracia Aparecida, Braga Walter Moisés Tobias, de Farias Danielle Leão Cordeiro, Bittencourt Rosane Isabel, Neto Jorge Vaz Pinto, Ribeiro Glaciano Nogueira, Bernardo Wanderley Marques, Tristão Luca, Magalhaes Roberto J P, Hungria Vânia Tietsche de Moraes

机构信息

Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil; Instituto Americas de Ensino e Pesquisa, Rio de Janeiro, RJ, Brazil.

Hospital Professor Edgar Santos da Universidade Federal da Bahia (HUPES-UFBA), Salvador, BA, Brazil.

出版信息

Hematol Transfus Cell Ther. 2022 Jul-Sep;44(3):410-418. doi: 10.1016/j.htct.2022.06.003. Epub 2022 Jul 20.

DOI:10.1016/j.htct.2022.06.003
PMID:35970751
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9477772/
Abstract
摘要