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传统肥胖参数在预测接受心脏导管检查的患者中狭窄冠状动脉(≥60%)数量的作用。

The role of traditional obesity parameters in predicting the number of stenosed coronary arteries (≥ 60%) among patients undergoing cardiac catheterization.

机构信息

Adult Health-Nursing Department, Faculty of Nursing, Jordan University of Science and Technology, P.O. Box: 3030, Irbid, 22110, Jordan.

出版信息

Sci Rep. 2022 Aug 15;12(1):13830. doi: 10.1038/s41598-022-17517-0.

DOI:10.1038/s41598-022-17517-0
PMID:35970873
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9378653/
Abstract

The correlation between obesity and coronary artery disease (CAD) has been well-documented in the literature. Body mass index, waist-height ratio, waist-hip ratio, body adiposity index, body shape index, waist circumference, and hip circumference are traditional obesity parameters used to measure obesity. This study aimed to investigate the role of these traditional obesity parameters in the prediction of the number of stenosed coronary arteries (≥ 60%) among patients undergoing cardiac catheterization. A descriptive cross-sectional study was conducted among 220 hospitalized patients undergoing cardiac catheterization in two hospitals in Jordan. Bivariate Pearson's correlation and forward linear regression analysis were used in the current study. Hip circumference was identified as being the best predictor of CAD (r = 0.5), with the best cut-off value of 103 cm (sensitivity = 0.92, specificity = 0.58). Hip circumference had significant regression levels with the number of stented coronary arteries (P = 0.002) and the number of severe stenosed coronary arteries (P = 0.04). The second-best obesity parameter in predicting CAD was waist circumference (r = 0.4), with a cut-off value of 0.95 m (sensitivity = 0.76, specificity = 0.68). High-sensitivity C-reactive protein (HS-CRP), triglycerides, and smoking had significant positive correlations with the number of stented coronary arteries (P < 0.05). Hip circumference of ≥ 103 cm, increased serum level of triglycerides, HS-CRP, and being a smoker are all factors which can predict CAD or the risk of developing it.

摘要

肥胖与冠状动脉疾病(CAD)之间的相关性在文献中已有充分记载。体重指数、腰高比、腰臀比、身体脂肪指数、身体形状指数、腰围和臀围是用于衡量肥胖的传统肥胖参数。本研究旨在探讨这些传统肥胖参数在预测接受心脏导管检查的患者狭窄冠状动脉(≥60%)数量中的作用。本研究在约旦的两家医院进行了一项针对 220 名住院接受心脏导管检查的患者的描述性横断面研究。本研究使用了双变量 Pearson 相关和向前线性回归分析。研究发现臀围是 CAD 的最佳预测指标(r=0.5),最佳截断值为 103cm(敏感性=0.92,特异性=0.58)。臀围与支架置入冠状动脉的数量(P=0.002)和严重狭窄冠状动脉的数量(P=0.04)具有显著的回归水平。预测 CAD 的第二佳肥胖参数是腰围(r=0.4),截断值为 0.95m(敏感性=0.76,特异性=0.68)。高敏 C 反应蛋白(hs-CRP)、甘油三酯和吸烟与支架置入冠状动脉的数量呈显著正相关(P<0.05)。臀围≥103cm、甘油三酯、hs-CRP 水平升高和吸烟均为预测 CAD 或发生 CAD 风险的因素。

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Higher circulating levels of ANGPTL8 are associated with body mass index, triglycerides, and endothelial dysfunction in patients with coronary artery disease.在冠心病患者中,循环中较高水平的 ANGPTL8 与体重指数、甘油三酯和内皮功能障碍有关。
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