Department of Stomatology, Hebei Eye Hospital, Xingtai, 054000, China.
Department of Haematology, The First Affiliated Hospital of Xingtai Medical College, Xingtai, 054000, China.
BMC Oral Health. 2022 Aug 15;22(1):352. doi: 10.1186/s12903-022-02387-9.
The calcification of the tooth pulp is a pathological condition that occurs in response to various factors. A uncommon haematological condition known as paroxysmal nocturnal haemoglobinuria (PNH) is characterized by bouts of haemolysis, and it requires long-term use of glucocorticoids (GCs).
A female patient who was diagnosed with PNH and had a history of long-term use of GCs came to our department for root canal therapy (RCT) for teeth 25, 26, and 27. The radiographs showed generalized pulp canal obliteration (PCO) in most of the patients. None of these teeth (25, 26, or 27) were sensitive to percussion, and they did not respond to thermal or electrical sensitivity tests. A diagnose of pulp necrosis was made for these teeth. RCT was carried out with the help of an oral microscope, and then a prosthodontic procedure was created for the teeth.
Based on the patient's long history use of GCs and a series of related studies, we conclude that the long-term usage of GCs contributes significantly to the onset of PCO.
牙髓钙化是一种由多种因素引起的病理状态。阵发性夜间血红蛋白尿症（PNH）是一种罕见的血液学疾病，其特征是阵发性溶血，需要长期使用糖皮质激素（GCs）。
一位女性患者被诊断为 PNH，长期使用 GCs，因牙 25、26 和 27 需要根管治疗（RCT）而到我科就诊。X 线片显示大多数患者的牙髓管普遍闭塞（PCO）。这些牙齿（25、26 或 27）均无叩诊痛，也无冷热电活力测试反应。因此诊断为牙髓坏死。在口腔显微镜的帮助下进行了 RCT，然后为这些牙齿制作了修复程序。
基于患者长期使用 GCs 的病史和一系列相关研究，我们得出结论，长期使用 GCs 显著导致 PCO 的发生。
