12426Lanzhou University, Lanzhou, China.
53045Chinese Academy of Sciences Lanzhou Branch, Lanzhou, China.
J Biomater Appl. 2022 Nov;37(5):930-941. doi: 10.1177/08853282221121886. Epub 2022 Aug 15.
The rapid degradation characteristics of magnesium alloys limit its application in the field of orthopedic fracture fixation and cardiovascular stents. This study aimed to improve the corrosion resistance and biocompatibility of AZ31 magnesium alloys and prepare degradable implant materials. Micro-arc oxidation (MAO) was used to change the concentration of yttrium acetate in the electrolyte to prepare coatings with different yttrium content on the surface of AZ31 magnesium alloy. Through characterization, it is proved that the yttrium in the coating mainly exists in the form of Y. The polarization potential experiment shows that the micro-arc oxidation coating significantly improves the corrosion resistance of magnesium alloys. With the increase of yttrium acetate concentration in the electrolyte, the corrosion resistance of the coating first increases and then weakens. When the concentration is 0.0035 mol/L, the coating has the highest corrosion resistance. The results of CCK-8 cytotoxicity experiment and cell morphology observation also proved that the cell viability in each group was greater than 140%, and the yttrium-doped coating on the surface of AZ31 magnesium alloy has no cytotoxicity, can promote cell growth, and has good biocompatibility.
镁合金的快速降解特性限制了其在骨科骨折固定和心血管支架领域的应用。本研究旨在提高 AZ31 镁合金的耐腐蚀性和生物相容性，制备可降解的植入材料。采用微弧氧化（MAO）技术改变电解液中醋酸钇的浓度，在 AZ31 镁合金表面制备出不同钇含量的涂层。通过表征，证明了涂层中的钇主要以 Y 的形式存在。极化电位实验表明，微弧氧化涂层显著提高了镁合金的耐腐蚀性。随着电解液中醋酸钇浓度的增加，涂层的耐腐蚀性先增强后减弱。当浓度为 0.0035 mol/L 时，涂层具有最高的耐腐蚀性。CCK-8 细胞毒性实验和细胞形态观察结果也证明，各组细胞的存活率均大于 140%，且 AZ31 镁合金表面掺杂钇的涂层无细胞毒性，能促进细胞生长，具有良好的生物相容性。
