Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea.
J Korean Med Sci. 2022 Aug 15;37(32):e251. doi: 10.3346/jkms.2022.37.e251.
Anaphylaxis to polyethylene glycol (PEG) is rare and mainly occurs with the use of laxatives containing PEG. Recently, an increasing number of PEG allergies have been reported, particularly those related to coronavirus disease 2019 (COVID-19) vaccines. mRNA COVID-19 vaccines, such as the BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) vaccines, contain PEG2000 as an excipient and are contraindicated when allergy to a vaccine component exist. We report a 55-year-old woman's history as a case of successful mRNA COVID-19 vaccination and colonoscopy after oral desensitization to PEG in a patient with PEG allergy who required both COVID-19 vaccination and colon evaluation. Allergy to PEG was diagnosed based on clinical history, skin test results, and basophil histamine release testing. Oral desensitization effectively suppressed histamine release from basophils in response to PEG stimulation, suggesting that oral desensitization using PEG-based laxatives may be an effective treatment option for patients with allergy to the substance.
对聚乙二醇（PEG）的过敏反应很少见，主要发生在使用含有 PEG 的泻药时。最近，越来越多的 PEG 过敏报告，特别是与 2019 年冠状病毒病（COVID-19）疫苗有关的过敏报告。信使 RNA（mRNA）COVID-19 疫苗，如 BNT162b2（辉瑞-生物技术公司）和 mRNA-1273（莫德纳）疫苗，含有 PEG2000 作为赋形剂，当对疫苗成分过敏时，疫苗是禁忌的。我们报告了一例 55 岁女性的病史，该患者在对 PEG 过敏的情况下，通过口服脱敏治疗成功接种了 mRNA COVID-19 疫苗并进行了结肠镜检查，该患者需要 COVID-19 疫苗接种和结肠评估。根据临床病史、皮肤试验结果和嗜碱性粒细胞组胺释放试验，诊断为对 PEG 的过敏。口服脱敏治疗有效抑制了嗜碱性粒细胞对 PEG 刺激的组胺释放，表明使用基于 PEG 的泻药进行口服脱敏治疗可能是对该物质过敏的患者的有效治疗选择。
