Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Road, Yuzhong District, Chongqing, 400016, China.
Eur J Trauma Emerg Surg. 2023 Aug;49(4):1665-1672. doi: 10.1007/s00068-022-02084-w. Epub 2022 Aug 16.
Fibrinogen is the substrate of plasma coagulation. It plays an important role in the formation of reticular network, which is crucial to the strength and stability of blood clots. In addition to directly participating in coagulation, fibrinogen also participates in the destruction of blood-brain barrier and neuroinflammation. This article reviews the pathophysiological changes of fibrinogen after traumatic brain injury. Considerable efforts have been made to understand the mechanisms by which fibrinogen damages the central nervous system. Combined with the latest research hotspots, potentially promising treatment strategies at the molecular level were discussed. We believe that understanding the role of fibrinogen-mediated damage in nerve and blood-brain barrier function will enable timely intervention in patients with nerve damage, and guide the development of novel targeted therapeutics.
纤维蛋白原是血浆凝血的底物。它在网状结构的形成中起着重要作用，这对血栓的强度和稳定性至关重要。除了直接参与凝血外，纤维蛋白原还参与血脑屏障的破坏和神经炎症。本文综述了创伤性脑损伤后纤维蛋白原的病理生理变化。人们已经做出了相当大的努力来了解纤维蛋白原损伤中枢神经系统的机制。结合最新的研究热点，讨论了在分子水平上有希望的治疗策略。我们相信，了解纤维蛋白原介导的损伤在神经和血脑屏障功能中的作用将能够及时干预神经损伤患者，并指导新型靶向治疗药物的开发。
