Clarke Lorelei L, Ratliff Cameron, Mans Christoph
Wisconsin Veterinary Diagnostic Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA,
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA.
J Avian Med Surg. 2022 Aug;36(2):187-191. doi: 10.1647/21-00013.
Regional limb perfusion (RLP) has been used to treat cases of distal limb infections in avian species. Potentially nephrotoxic drugs, such as amikacin, may increase the risk of nephrotoxicity with RLP because of the presence of the renal portal system and direct venous blood flow from the pelvic limbs to the kidneys. In a randomized, blinded, placebo-controlled study, the safety of repeated amikacin administration (20 mg/kg q24h for 3 doses) via RLP was evaluated in healthy female chickens (; n = 8 treatment, n = 8 saline control group). Plasma uric acid concentrations were not significantly elevated in treated birds compared with the control group at any time point following RLP. One week following the final RLP, birds were necropsied and the kidneys evaluated grossly and histologically. There was no significant difference in renal pathology scores between treated and control birds or between kidneys ipsilateral to the perfused limb and contralateral kidneys. This study concludes that RLP of amikacin at high doses produced no discernable renal pathology in healthy euhydrated chickens.
区域肢体灌注（RLP）已被用于治疗禽类的远端肢体感染。由于存在肾门静脉系统以及从盆腔肢体到肾脏的直接静脉血流，潜在的肾毒性药物，如阿米卡星，可能会增加RLP导致肾毒性的风险。在一项随机、双盲、安慰剂对照研究中，对健康雌性鸡（治疗组n = 8，生理盐水对照组n = 8）通过RLP重复给予阿米卡星（20 mg/kg，每24小时一次，共3剂）的安全性进行了评估。在RLP后的任何时间点，与对照组相比，治疗组鸡的血浆尿酸浓度均未显著升高。在最后一次RLP后一周，对鸡进行剖检，并对肾脏进行大体和组织学评估。治疗组和对照组鸡之间，以及灌注肢体同侧肾脏和对侧肾脏之间的肾脏病理评分均无显著差异。本研究得出结论，在健康的水合正常鸡中，高剂量阿米卡星的RLP未产生可辨别的肾脏病理变化。
