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用泊洛沙姆 407 中注射用卡铂治疗非洲灰鹦鹉复发性多发性皮肤鳞状细胞癌。

Treatment of Recurrent Multifocal Cutaneous Squamous Cell Carcinoma in an African Grey Parrot () with Intralesional Carboplatin in Poloxamer 407.

机构信息

NorthCoast Bird and Exotic Specialty Hospital, Norton, OH 44203, USA,

NorthCoast Bird and Exotic Specialty Hospital, Norton, OH 44203, USA.

出版信息

J Avian Med Surg. 2022 Aug;36(2):200-205. doi: 10.1647/21-00010.

DOI:10.1647/21-00010
PMID:35972873
Abstract

A 16-year-old male Congo African grey parrot () was presented with an ulcerated wing mass that was excised and diagnosed on histopathology as squamous cell carcinoma (SCC). A second surgery was performed to completely excise the tumor margins, resulting in over 5 years of remission for the neoplasm. However, over the next 6 years the patient developed SCC in 3 new locations on the body, as well as 2 squamous papillomas. The 2 papillomas were surgically excised and did not recur. Due to their size and location, none of the 3 new SCCs were amenable to complete excision. Instead, the 3 SCCs were managed with a series of treatments with intralesional carboplatin in poloxamer 407 and carbon dioxide surgical laser debridements. This treatment regimen has resulted in long-term (52 months, 30 months, and 17 months) resolution for all 3 of the SCCs. The overall survival time for the patient, from the initial diagnosis to the time of this report, is over 2900 days. While being treated for the 3 SCCs, the African grey parrot had no overt signs of complications or adverse side effects.

摘要

一只 16 岁的雄性刚果非洲灰鹦鹉()因翅膀溃疡性肿块就诊,经组织病理学诊断为鳞状细胞癌(SCC)。进行了第二次手术以完全切除肿瘤边缘,使肿瘤缓解超过 5 年。然而,在接下来的 6 年中,该患者在身体的 3 个新部位和 2 个鳞状乳头状瘤中又发生了 SCC。2 个乳头状瘤通过手术切除,没有复发。由于其大小和位置,3 个新的 SCC 中没有一个可以完全切除。相反,这 3 个 SCC 采用了一系列治疗方法,包括用泊洛沙姆 407 包埋的卡铂和二氧化碳手术激光清创术。这种治疗方案使所有 3 个 SCC 都得到了长期(52 个月、30 个月和 17 个月)缓解。从最初诊断到本报告时,该患者的总生存时间超过 2900 天。在治疗这 3 个 SCC 的过程中,非洲灰鹦鹉没有明显的并发症或不良反应迹象。

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Treatment of Recurrent Multifocal Cutaneous Squamous Cell Carcinoma in an African Grey Parrot () with Intralesional Carboplatin in Poloxamer 407.用泊洛沙姆 407 中注射用卡铂治疗非洲灰鹦鹉复发性多发性皮肤鳞状细胞癌。
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