拉贝洛尔治疗妊娠期高血压后出现芬太尼尿检测假阳性：1 例报告。
False-positive Fentanyl Urine Detection after Initiation of Labetalol Treatment for Hypertension in Pregnancy: A Case Report.
机构信息
From the Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston, MA (AW); Wake Forest School of Medicine, Winston-Salem, NC (BCI); Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston, MA (KS); College of Education, Oregon State University, Corvallis, OR (TAF).
出版信息
J Addict Med. 2022;16(6):e417-e419. doi: 10.1097/ADM.0000000000001010. Epub 2022 Aug 17.
BACKGROUND
Labetalol hydrochloride (LH) is a pharmacologic treatment for hypertensive disease (HD) in pregnancy. However, for pregnant persons with substance use disorders (SUDs), LH may interfere with urine drug testing.
CASE SUMMARY
We present 3 pregnant or postpregnant persons with SUDs who experienced presumptive positive urine immunoassays for fentanyl while prescribed LH for perinatal HD.
DISCUSSION
Labetalol hydrochloride treatment for HD in pregnancy can result in presumptive positive urine immunoassays for fentanyl. Unrecognized or misinterpreted, this phenomenon can lead to significant consequences for pregnant and postpartum persons with co-occurring substance use and hypertensive disorders. Clinicians caring for pregnant persons with SUDs must be aware of this phenomenon and its sequelae when ordering and interpreting urine immunoassays for fentanyl.
背景
盐酸拉贝洛尔（LH）是治疗妊娠高血压疾病（HD）的一种药物。然而，对于患有物质使用障碍（SUD）的孕妇，LH 可能会干扰尿液药物检测。
病例摘要
我们介绍了 3 名患有 SUD 的孕妇或产后妇女，她们在因围产期 HD 而开 LH 治疗期间，尿液免疫分析检测到疑似芬太尼阳性。
讨论
妊娠期间用 LH 治疗 HD 可能导致芬太尼尿液免疫分析出现假阳性。如果未被识别或被错误解释，这种现象可能会对同时患有物质使用障碍和高血压疾病的孕妇和产后妇女产生重大影响。当对芬太尼进行尿液免疫分析时，治疗患有 SUD 的孕妇的临床医生必须意识到这种现象及其后果。
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