Department of Pediatrics, Institution of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Region Västra Götaland, Department of Pediatrics, The Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden.
Pediatr Res. 2023 Mar;93(4):924-931. doi: 10.1038/s41390-022-02236-z. Epub 2022 Aug 16.
Necrotizing enterocolitis (NEC) affects the intestine of preterm infants. Preterm infants risk inadequate bone mineralization. This risk may increase if the intestinal uptake of minerals is affected after NEC.
This is a study of growth, bone mineral density (BMD), bone mineral content (BMC), and body composition at 5 years of age among Swedish children born before gestational week 37 + 0 with a history of NEC, minimum stage IIA, compared to matched controls. Fifty children, 25 NEC cases and 25 controls, were examined with dual energy X-ray absorptiometry (DXA) and DXA with laser.
The NEC cases had lower weight, -1.3 SDS vs -0.7 SDS, a lower fat mass and fat percent, 23.4 vs 29.1%, compared to the controls. NEC cases had lower BMC total body head excluded, 355.6 g vs 416.7 g. BMD Z-scores were lower among NEC cases in total body head excluded, -0.7 vs -0.1, and in lumbar spine.
Preterm NEC survivors at 5 years of age had reduced growth, an altered body composition, and indications of a lower bone mass compared to matched controls. The study suggests that preterm infants diagnosed with NEC need special attention during childhood regarding growth and bone health.
A follow-up longitudinal study of growth, bone health, and body composition at 5 years of age among children born preterm with a history of NEC compared to matched controls. The NEC cases had lower weight than controls. NEC cases had an altered body composition with lower fat mass compared to controls. The DXA results showed that the NEC cases had lower bone mineral content and a tendency to lower bone mineral density. The study suggests that preterm infants diagnosed with NEC need special attention at follow-up regarding growth and bone health compared to preterm infants without NEC.
坏死性小肠结肠炎（NEC）影响早产儿的肠道。早产儿存在矿物质骨矿化不足的风险。如果 NEC 后肠道对矿物质的吸收受到影响，这种风险可能会增加。
这是一项在瑞典出生胎龄<37+0 周、有 NEC 病史（最低 2A 期）的儿童中，研究其 5 岁时生长、骨密度（BMD）、骨矿物质含量（BMC）和身体成分的研究。通过双能 X 射线吸收法（DXA）和激光 DXA 对 50 名儿童（25 名 NEC 患儿和 25 名匹配对照）进行了检查。
与对照组相比，NEC 患儿的体重较低，为-1.3 SDS 比-0.7 SDS，体脂和体脂百分比也较低，分别为 23.4%比 29.1%。NEC 患儿的全身头部排除 BMC 总含量也较低，为 355.6 g 比 416.7 g。全身头部排除时，NEC 患儿的 BMD 评分较低，为-0.7 比-0.1，腰椎也较低。
5 岁时患有 NEC 的早产儿幸存者与匹配对照组相比，生长发育迟缓，身体成分发生改变，骨量减少。研究表明，患有 NEC 的早产儿在儿童期需要特别关注生长和骨骼健康。
一项针对出生时患有 NEC 的早产儿与匹配对照组在 5 岁时进行生长、骨骼健康和身体成分的随访纵向研究。NEC 患儿的体重低于对照组。与对照组相比，NEC 患儿的身体成分发生改变，体脂量较低。DXA 结果显示，NEC 患儿的 BMC 含量较低，且 BMC 密度有降低的趋势。与没有 NEC 的早产儿相比，患有 NEC 的早产儿在随访中需要特别关注生长和骨骼健康。
