CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, P. R. China.
University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
Chem Asian J. 2022 Oct 4;17(19):e202200675. doi: 10.1002/asia.202200675. Epub 2022 Sep 1.
Nanopores, due to their advantages of being modifiable, controllability and sensitivity, have made a splash in recent years in the fields of biomolecular sequencing, small molecule detection, salt differential power generation, and biomimetic ion channels. In these applications, the role of chemical or biological modification is indispensable. Compared with small molecules, the modification of polymers is more difficult and the methods are more diverse. Choosing an appropriate modification method directly determines the success or failure of a research project; therefore, it is necessary to summarize polymer modification methods toward nanopores. In addition, it is also important to provide clear and convincing evidence that the nanopore modification is successful, the corresponding characterization methods are also indispensable. Therefore, this review will summarize the methods of polymer modification of nanopores and efficient characterization methods. We hope that this review will provide some reference value for like-minded researchers.
纳米孔由于其可修饰性、可控性和灵敏度的优势，近年来在生物分子测序、小分子检测、盐差发电和仿生离子通道等领域引起了轰动。在这些应用中，化学或生物修饰的作用是不可或缺的。与小分子相比，聚合物的修饰更加困难，方法也更加多样化。选择合适的修饰方法直接决定了研究项目的成败；因此，有必要总结聚合物修饰纳米孔的方法。此外，提供清晰、令人信服的证据证明纳米孔修饰成功也是很重要的，相应的表征方法也是必不可少的。因此，本综述将总结纳米孔聚合物修饰的方法和高效的表征方法。我们希望本综述能为有兴趣的研究人员提供一些参考价值。
