Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, P. R. China.
Chem Asian J. 2022 Nov 16;17(22):e202200775. doi: 10.1002/asia.202200775. Epub 2022 Sep 23.
Nanopore technology is a burgeoning detection technology for single-molecular sensing and ion rectification. Solid-state nanopores have attracted more and more attention because of their higher stability and tunability than biological nanopores. However, solid-state nanopores still suffer the drawbacks of low signal-to-noise ratio and low resolution, which hinder their practical applications. Thus, developing operatical and useful methods to overcome the shortages of solid-state nanopores is urgently needed. Here, we summarize the recent research on nanopore modification to achieve this goal. Modifying solid-state nanopores with different coating molecules can improve the selectivity, sensitivity, and stability of nanopores. The modified molecules can introduce different functions into the nanopores, greatly expanding the applications of this novel detection technology. We hope that this review of nanopore modification will provide new ideas for this field.
纳米孔技术是一种新兴的单分子传感和离子整流检测技术。由于固态纳米孔比生物纳米孔具有更高的稳定性和可调性，因此越来越受到关注。然而，固态纳米孔仍然存在信噪比和分辨率低的缺点，这阻碍了它们的实际应用。因此，开发实用的方法来克服固态纳米孔的不足是当务之急。在这里，我们总结了最近关于纳米孔修饰以实现这一目标的研究。用不同的涂层分子修饰固态纳米孔可以提高纳米孔的选择性、灵敏度和稳定性。修饰后的分子可以为纳米孔引入不同的功能，极大地扩展了这项新型检测技术的应用。我们希望对纳米孔修饰的综述能为该领域提供新的思路。
