Nikpour Shahriar, Salehi Mohammad, Homaee Sina, Saberian Farnaz, Kalbasi Saeid
Internal Ward, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Internal Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Caspian J Intern Med. 2022 Summer;13(3):567-574. doi: 10.22088/cjim.13.3.567.
Various ways of treating H.pylori infection are reported, such as triple-therapy and quadruple therapy for two weeks. Some side effects have been seen during these treatments, besides Helicobacter pylori becoming resistant to these antibiotics easily. According to some studies, there is a relationship between metformin and reduction in Helicobacter pylori infection. Thus, in this study, we determine the effects of metformin on Helicobacter pylori infection.
We performed this assessment in a randomized, case-controlled way in the diagnosis of Helicobacter pylori infected outpatients and inpatients. In both groups (case group and control group), patients took two tablets for a two-week period. In the case group, the patients were given two metformin tablets (each containing 500mg of metformin (extended release) and in the control group, they were given two placebo tablets (each containing 500mg of white flour). We took h.pylori Ag stool test and rapid urease test to confirm the presence of Helicobacter pylori infection.
In this study, at first all the patients had positive h.pylori Ag stool test or positive rapid urease test. At the end of this study, the results of h.pylori Ag stool*- test presented that Helicobacter pylori infection was negative in 82.7% of the case group patients and 76% of control group patients which illustrates suppression of Helicobacter pylori infection. However, comparing to the control group (P=0.36), this difference was not statistically remarkable.
According to these findings, it is stated that having metformin along with prescribed antibiotics can help decrease Helicobacter pylori infection.
有多种治疗幽门螺杆菌感染的方法被报道，比如为期两周的三联疗法和四联疗法。在这些治疗过程中出现了一些副作用，此外幽门螺杆菌很容易对这些抗生素产生耐药性。根据一些研究，二甲双胍与幽门螺杆菌感染的减少之间存在关联。因此，在本研究中，我们确定二甲双胍对幽门螺杆菌感染的影响。
我们以随机、病例对照的方式对幽门螺杆菌感染的门诊和住院患者进行了此项评估。在两组（病例组和对照组）中，患者在两周内每天服用两片药。病例组患者服用两片二甲双胍片（每片含500毫克二甲双胍（缓释）），对照组患者服用两片安慰剂片（每片含500毫克白面粉）。我们进行了幽门螺杆菌抗原粪便检测和快速尿素酶试验以确认幽门螺杆菌感染的存在。
在本研究中，起初所有患者的幽门螺杆菌抗原粪便检测或快速尿素酶试验均为阳性。在本研究结束时，幽门螺杆菌抗原粪便检测结果显示，病例组82.7%的患者和对照组76%的患者幽门螺杆菌感染呈阴性，这表明幽门螺杆菌感染受到了抑制。然而，与对照组相比（P = 0.36），这种差异无统计学意义。
根据这些发现，表明同时服用二甲双胍和规定的抗生素有助于减少幽门螺杆菌感染。
