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高危患者冠状动脉搭桥术后吸气肌训练与功能能力:一项随机对照试验的初步研究。

Inspiratory muscle training and functional capacity following coronary artery bypass grafting in high-risk patients: A pilot randomized and controlled trial.

作者信息

Cordeiro André Luiz Lisboa, Carvalho Bianca Silva Cavalcante De, Silva Eduarda Gomes Da, Santos Natália Da Silva, de Melo Thiago Araújo, Guimarães André Raimundo França, Petto Jefferson

机构信息

Department of Physiotherapy, Faculdade Nobre, Feira de Santana, Brazil.

Department of Medicine and Human Health, Escola Bahiana de Medicina e Saúde Pública, Salvador, Brazil.

出版信息

J Clin Transl Res. 2022 Jun 17;8(4):266-271. eCollection 2022 Aug 29.

Abstract

BACKGROUND

Coronary artery bypass graft (CABG) surgery is associated with worsened functional capacity, pulmonary complications, and increased length of hospital stay. These negative effects are exacerbated in patients who are at high risk of post-operative (PO) pulmonary complications before CABG. Inspiratory muscle training (IMT) has been shown to benefit CABG patients in their recovery process. However, in high-risk patients, there is little evidence to support the post-operative implementation of IMT for purposes of faster recovery.

AIM

The aim of the study was to test the hypothesis that IMT improves the functional capacity, pulmonary complications, and length of hospital stay in patients prone to pulmonary complications who had undergone CABG.

METHODS

This is a pilot clinical trial carried out with patients at high risk for pulmonary complications in the PO phase. In the pre-operative period, maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP), and 6-min walk test (6MWT) were determined and administered. On the first PO day, patients were divided into two groups: A control group (CG) that received routine intervention and an IMT group that, in addition to routine care, was subjected to an IMT protocol until hospital discharge. On the day of discharge, the patients were reassessed with respect to ventilatory muscle strength, functional capacity, PO complications, and length of stay.

RESULTS

Twenty-nine patients were evaluated, 15 in the CG and 14 in the IMT group. No significant differences were observed in relation to MIP (difference between the mean of -7 cmHO; 95% CI = -16.52-2.52), MEP (difference between the mean of -7cm HO; 95% CI = -15.39-1.39), and in the 6MWT (difference between the mean of -9 m; 95% CI = -43.71-25.71). There was a decrease in the length of stay in the IMT group compared to the CG (9 ± 3 vs. 12 ± 4 days; = 0.04). The IMT group had a lower rate of atelectasis and pneumonia.

CONCLUSION

IMT does not minimize the loss of functional capacity, but it reduces pulmonary complications and the length of stay of patients undergoing CABG who are preoperatively at a high risk of pulmonary complications.

RELEVANCE FOR PATIENTS

The increase in ventilatory muscle strength, associated with IMT, can reduce PO pulmonary complications, resulting in shorter hospital stays, and improved quality of life.

摘要

背景

冠状动脉旁路移植术(CABG)手术会导致功能能力下降、肺部并发症以及住院时间延长。这些负面影响在冠状动脉旁路移植术前术后肺部并发症高风险患者中会加剧。吸气肌训练(IMT)已被证明对冠状动脉旁路移植术患者的恢复过程有益。然而,在高风险患者中,几乎没有证据支持术后进行吸气肌训练以实现更快恢复。

目的

本研究的目的是验证以下假设:吸气肌训练可改善冠状动脉旁路移植术后易发生肺部并发症患者的功能能力、肺部并发症及住院时间。

方法

这是一项针对术后肺部并发症高风险患者开展的试点临床试验。在术前阶段,测定并实施最大吸气压力(MIP)、最大呼气压力(MEP)和6分钟步行试验(6MWT)。术后第一天,患者被分为两组:接受常规干预的对照组(CG)和除常规护理外还接受吸气肌训练方案直至出院的吸气肌训练组。出院当天,对患者的通气肌肉力量、功能能力、术后并发症及住院时间进行重新评估。

结果

共评估了29例患者,对照组15例,吸气肌训练组14例。在最大吸气压力(平均差值为-7cmH₂O;95%CI=-16.52 - 2.52)、最大呼气压力(平均差值为-7cmH₂O;95%CI=-15.39 - 1.39)和6分钟步行试验(平均差值为-9m;95%CI=-43.71 - 25.71)方面未观察到显著差异。与对照组相比,吸气肌训练组的住院时间有所缩短(9±3天对12±4天;P=0.04)。吸气肌训练组肺不张和肺炎的发生率较低。

结论

吸气肌训练并不能使功能能力的丧失最小化,但可减少冠状动脉旁路移植术患者的肺部并发症及住院时间,这些患者术前肺部并发症风险较高。

对患者的意义

与吸气肌训练相关的通气肌肉力量增强可减少术后肺部并发症,从而缩短住院时间并改善生活质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e74c/9373720/375603c22f0c/jclintranslres-2022-8-4-266-g001.jpg

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