接受重组α2干扰素治疗的患者中观察到可逆性心律失常。
Reversible arrhythmias observed in patients treated with recombinant alpha 2 interferon.
作者信息
Martino S, Ratanatharathorn V, Karanes C, Samal B A, Sohn Y H, Rudnick S A
出版信息
J Cancer Res Clin Oncol. 1987;113(4):376-8. doi: 10.1007/BF00397722.
Abstract
We have treated 25 patients, 7 with breast cancer and 18 with non-Hodgkin's lymphoma, with recombinant alpha 2 interferon. In 5 patients we observed cardiac arrhythmias that were unexpected and required treatment. No deaths have occurred that we can attribute to interferon, though 1 patient had to be resuscitated. Age, prior cardiac disease, prior treatment with doxorubicin, and interferon dose appear to be predisposing factors for this toxicity.
摘要
我们用重组α2干扰素治疗了25例患者，其中7例患有乳腺癌，18例患有非霍奇金淋巴瘤。在5例患者中，我们观察到了意外发生且需要治疗的心律失常。虽然有1例患者需要进行复苏，但没有发生可归因于干扰素的死亡病例。年龄、既往心脏病史、既往使用阿霉素治疗以及干扰素剂量似乎是这种毒性的诱发因素。
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本文引用的文献
1
Common pathways of interferon and hormonal action.干扰素与激素作用的共同途径。
Nature. 1980 Jan 24;283(5745):406-8. doi: 10.1038/283406a0.
2
Phase-I trial of UltrapureTM human leukocyte interferon in human malignancy.超纯TM人白细胞干扰素在人类恶性肿瘤中的I期试验。
Cancer Chemother Pharmacol. 1984;12(1):39-42. doi: 10.1007/BF00255907.
3
Treatment of advanced non-Hodgkin's lymphoma with recombinant leukocyte A interferon.用重组白细胞A干扰素治疗晚期非霍奇金淋巴瘤。
N Engl J Med. 1984 Nov 1;311(18):1148-52. doi: 10.1056/NEJM198411013111803.
4
[Clinical trial of human lymphoblastoid interferon on advanced malignancy].人淋巴母细胞干扰素治疗晚期恶性肿瘤的临床试验
Gan To Kagaku Ryoho. 1983 Nov;10(11):2324-9.
5
Interferons in the treatment of human cancer.干扰素在人类癌症治疗中的应用。
J Clin Oncol. 1984 Apr;2(4):336-52. doi: 10.1200/JCO.1984.2.4.336.
6
Alpha(human leukocyte)-interferon as treatment for non-small cell carcinoma of the lung: a phase II trial.
J Biol Response Mod. 1983;2(4):343-7.
7
Deaths halt interferon trials in France.法国的干扰素试验因死亡事件而暂停。
Science. 1982 Nov 19;218(4574):772. doi: 10.1126/science.6182613.
8
Interferon inhibits cardiac cell function in vitro.干扰素在体外抑制心脏细胞功能。
Proc Soc Exp Biol Med. 1981 Feb;166(2):181-5. doi: 10.3181/00379727-166-41043.
9
Interferon enhances the excitability of cultured neurones.干扰素可增强培养神经元的兴奋性。
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