Martino S, Ratanatharathorn V, Karanes C, Samal B A, Sohn Y H, Rudnick S A
J Cancer Res Clin Oncol. 1987;113(4):376-8. doi: 10.1007/BF00397722.
We have treated 25 patients, 7 with breast cancer and 18 with non-Hodgkin's lymphoma, with recombinant alpha 2 interferon. In 5 patients we observed cardiac arrhythmias that were unexpected and required treatment. No deaths have occurred that we can attribute to interferon, though 1 patient had to be resuscitated. Age, prior cardiac disease, prior treatment with doxorubicin, and interferon dose appear to be predisposing factors for this toxicity.
我们用重组α2干扰素治疗了25例患者，其中7例患有乳腺癌，18例患有非霍奇金淋巴瘤。在5例患者中，我们观察到了意外发生且需要治疗的心律失常。虽然有1例患者需要进行复苏，但没有发生可归因于干扰素的死亡病例。年龄、既往心脏病史、既往使用阿霉素治疗以及干扰素剂量似乎是这种毒性的诱发因素。
