Matsuura Akihisa, Ano Yusuke, Chatani Naoto
Department of Applied Chemistry, Faculty of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Research Center for Environmental Preservation, Osaka University, 2-4 Yamadaoka, Suita, Osaka 565-0871, Japan.
Chem Commun (Camb). 2022 Sep 1;58(71):9898-9901. doi: 10.1039/d2cc02999e.
Nucleophilic aromatic substitution (SAr) reactions of non-activated aryl fluorides with amide enolates are reported. The reaction proceeds under relatively mild reaction conditions. Lactams also participate in the reaction to give 2-arylated lactams. DFT calculations suggest that the reaction proceeds through a concerted SAr pathway.
报道了未活化芳基氟化物与酰胺烯醇盐的亲核芳香取代（SAr）反应。该反应在相对温和的反应条件下进行。内酰胺也参与反应生成2-芳基内酰胺。密度泛函理论计算表明该反应通过协同的SAr途径进行。
