Department of Cardiothoracic and Vascular Surgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
University Health Care Research Centre, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Braz J Cardiovasc Surg. 2022 Aug 16;37(4):430-438. doi: 10.21470/1678-9741-2021-0576.
To compare health-related quality of life (HRQoL) of patients primarily treated with a no-touch saphenous vein graft with that of patients who received a conventional graft.
The study included all individuals treated with a percutaneous coronary intervention (PCI) on a saphenous vein graft (SVG) between January 2006 and June 2020. The RAND-36 health survey was used to assess HRQoL. The Mann-Whitney U test was used to test differences in HRQoL between the two groups. Effect size was estimated via Cohen's d. The average treatment effect between the groups was tested by propensity score matching (PSM).
Of the 346 patients treated with a PCI in a stenosed or occluded SVG, 165 responded to RAND-36 (no-touch: n=48; conventional: n=117). Patients with a no-touch graft reported better mean values on seven of the eight health survey domains. Statistically significant differences were observed for four of the domains, all in favour of the no-touch group. The effect size estimates indicated a small difference for five domains, with the highest values (>0.40) seen for the general health and energy/fatigue domains. PSM confirmed a statistically significant difference for the physical functioning and general health domains.
At a mean follow-up of 5.4 years, patients who received a PCI in no-touch vein grafts showed significantly better HRQoL than those who received a PCI in conventional vein grafts.
比较主要接受无接触隐静脉移植物治疗的患者与接受常规移植物治疗的患者的健康相关生活质量（HRQoL）。
该研究纳入了 2006 年 1 月至 2020 年 6 月期间所有接受经皮冠状动脉介入治疗（PCI）的隐静脉移植物（SVG）患者。采用 RAND-36 健康调查评估 HRQoL。采用曼-惠特尼 U 检验比较两组 HRQoL 的差异。采用 Cohen's d 估计效应大小。采用倾向评分匹配（PSM）检验两组间的平均治疗效果。
在 346 例因 SVG 狭窄或闭塞而行 PCI 的患者中，有 165 例对 RAND-36 做出了回应（无接触组：n=48；常规组：n=117）。无接触移植物组的 8 个健康调查领域中有 7 个领域的平均评分较高。四个领域的差异具有统计学意义，均有利于无接触组。效应大小估计值表明，有五个领域存在较小的差异，其中一般健康和精力/疲劳领域的得分最高（>0.40）。PSM 证实了无接触组和常规组在生理功能和一般健康领域的差异具有统计学意义。
在平均随访 5.4 年后，接受无接触静脉移植物 PCI 的患者的 HRQoL 明显优于接受常规静脉移植物 PCI 的患者。
