超广角荧光素血管造影中视网膜静脉阻塞眼的视网膜血管床面积：WAVE 研究。

RETINAL VASCULAR BED AREA IN EYES WITH RETINAL VEIN OCCLUSION ON ULTRA-WIDEFIELD FLUORESCEIN ANGIOGRAPHY: WAVE Study.

机构信息

Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Sciences Key, Laboratory, Capital Medical University, Beijing, China.

Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California.

出版信息

Retina. 2022 Oct 1;42(10):1883-1888. doi: 10.1097/IAE.0000000000003549.

DOI:10.1097/IAE.0000000000003549

PMID:35976232

Abstract

PURPOSE

To compute retinal vascular bed area (RVBA) in square millimeters on distortion corrected ultra-widefield fluorescein angiography images in eyes with retinal vein occlusion (RVO).

METHODS

Prospective observational study. The peripheral distortion of baseline ultra-widefield fluorescein angiography (Optos 200Tx) images of 30 patients with RVO from the WAVE study (NCT01710839) and 13 control eyes of normal subjects was corrected using the stereographic projection method to compute RVBA in square millimeters.

RESULTS

In comparison with age- and sex-matched normal control eyes, eyes with RVO had a decreased global RVBA for the entire retina (50.5 ± 20.4 mm 2 vs. 62.6 ± 12.2 mm 2 , P = 0.023). Eyes with RVO and the unaffected fellow eye had a similar RVBA globally (50.5 ± 20.4 mm 2 vs. 46.2 ± 18.9 mm 2 , P = 0.523). The RVBA was observed to negatively correlate with nonperfusion area (R = -0.47, P = 0.009). However, RVBA was not related to the severity of macular edema ( P > 0.05).

CONCLUSION

Eyes with RVO have a similar RVBA to the unaffected fellow eyes but with a reduction when compared with normal control eyes. Retinal vascular bed area appears to be a surrogate biomarker of retinal ischemia on ultra-widefield fluorescein angiography but not the extent of macular edema.

摘要

目的

在视网膜静脉阻塞（RVO）患者的眼底荧光血管造影图像上计算经失真校正后的视网膜血管床面积（RVBA），单位为平方毫米。

方法

前瞻性观察性研究。使用立体投影法校正 WAVE 研究（NCT01710839）中 30 例 RVO 患者和 13 例正常受试者基线超广角荧光素血管造影（Optos 200Tx）图像的周边失真，以计算平方毫米的 RVBA。

结果

与年龄和性别匹配的正常对照组相比，RVO 患者的整个视网膜的全局 RVBA 减少（50.5 ± 20.4 mm2 与 62.6 ± 12.2 mm2，P = 0.023）。RVO 眼和未受影响的对侧眼的全局 RVBA 相似（50.5 ± 20.4 mm2 与 46.2 ± 18.9 mm2，P = 0.523）。RVBA 与无灌注区呈负相关（R = -0.47，P = 0.009）。然而，RVBA 与黄斑水肿的严重程度无关（P > 0.05）。