Universidade de São Paulo, Hospital das Clínicas, Divisão de Laboratório Clínico, Laboratório de Líquido Cefalorraquidiano, São Paulo SP, Brazil.
Universidade de São Paulo, Departamento de Neurologia, São Paulo SP, Brazil.
Arq Neuropsiquiatr. 2022 May;80(5 Suppl 1):290-295. doi: 10.1590/0004-282X-ANP-2022-S114.
Cerebrospinal fluid (CSF) analysis is an important diagnostic tool for many conditions affecting the central nervous system (CNS), especially CNS infectious diseases. Despite its low specificity, CSF white blood cell counts, CSF protein levels, CSF serum glucose ratio and CSF lactate measurement are useful in differentiating infections caused by distinct groups of pathogens. CSF direct examination and cultures can identify causative organisms and antibiotic sensitivities as well. Adjunctive tests such as latex agglutination, different immunological assays and molecular reactions have great specificities and increasing sensitivities. In this article, some recent diagnostic methods applied to CSF analysis for frequent CNS infections are presented.
脑脊液（CSF）分析是许多影响中枢神经系统（CNS）的疾病的重要诊断工具，尤其是 CNS 感染性疾病。尽管特异性较低，但 CSF 白细胞计数、CSF 蛋白水平、CSF 血清葡萄糖比值和 CSF 乳酸测量有助于区分不同病原体引起的感染。CSF 直接检查和培养也可以鉴定病原体和抗生素敏感性。乳胶凝集、不同的免疫学检测和分子反应等辅助检测具有很高的特异性和不断提高的敏感性。本文介绍了一些最近应用于 CSF 分析的诊断方法，用于常见的 CNS 感染。
