血清白细胞衍生趋化因子2（LECT2）水平与骨质疏松症相关。
Serum Leukocyte Cell-Derived Chemotaxin 2 (LECT2) Level Is Associated with Osteoporosis.
作者信息
Wang Qiang, Xu Feng, Chen Jiong, Xie Yan-Qing, Xu Su-Ling, He Wen-Ming
机构信息
Affiliated Hospital of Medical School of Ningbo University, Ningbo, Zhejiang, China.
Laboratory of Biochemistry and Molecular Biology, School of Marine Sciences, Meishan Campus, Ningbo University, Ningbo, Zhejiang, China.
出版信息
Lab Med. 2023 Jan 5;54(1):106-111. doi: 10.1093/labmed/lmac080.
OBJECTIVE
The aim of this study was to examine serum leukocyte cell-derived chemotaxin 2 (LECT2) levels in osteoporosis subjects to confirm its association with osteoporosis.
METHODS
A total of 204 adult subjects were recruited. Bone mineral densities (BMD) were assessed and blood samples were collected for measurements of biomedical parameters and the bone turnover markers. Serum LECT2 levels were measured by enzyme-linked immunosorbent assay. The relationships between serum LECT2 levels and other parameters were analyzed using the Spearman correlation coefficient.
RESULTS
Serum LECT2 levels were significantly increased in osteoporosis subjects over controls. We found a significantly negative correlation of serum LECT2 with BMD, 25-hydroxy-vitamin D, and creatinine and a significantly positive correlation with C-terminal telopeptide of type 1 collagen and total cholesterol.
CONCLUSION
Serum LECT2 levels were significantly upregulated in osteoporosis subjects and correlated with the severity of bone loss. Serum LECT2 could be a potential biomarker to assess the risk of bone loss.
目的
本研究旨在检测骨质疏松症患者血清白细胞衍生趋化因子2（LECT2）水平，以确认其与骨质疏松症的关联。
方法
共招募了204名成年受试者。评估骨密度（BMD）并采集血样，用于测量生物医学参数和骨转换标志物。采用酶联免疫吸附测定法测量血清LECT2水平。使用Spearman相关系数分析血清LECT2水平与其他参数之间的关系。
结果
与对照组相比，骨质疏松症患者血清LECT2水平显著升高。我们发现血清LECT2与骨密度、25-羟基维生素D和肌酐呈显著负相关，与Ⅰ型胶原C端肽和总胆固醇呈显著正相关。
结论
骨质疏松症患者血清LECT2水平显著上调，并与骨质流失的严重程度相关。血清LECT2可能是评估骨质流失风险的潜在生物标志物。
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