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Insulin-like growth factor-I modulates endothelial cell chemotaxis.

作者信息

Grant M, Jerdan J, Merimee T J

出版信息

J Clin Endocrinol Metab. 1987 Aug;65(2):370-1. doi: 10.1210/jcem-65-2-370.

DOI:10.1210/jcem-65-2-370
PMID:3597713
Abstract

Insulin-like growth factor-I (IGF-I) significantly promoted chemotaxis in three separate endothelial cell lines at concentrations ranging from 4 to 150 ng/ml. When added to minimum essential medium (MEM) supplemented with 1% fetal calf serum, IGF-I augmented chemotaxis to a level equalling the maximal chemotactic effect obtainable with MEM supplemented with 10% fetal calf serum (FCS 10%). The data are compatible with a potential role for IGF-I in neovascularization.

摘要

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