Unit of Psychiatry, Department of Public Health and Medicinal Administration, & Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao SAR, China.
Centre for Cognitive and Brain Sciences, University of Macau, Macao SAR, China.
Age Ageing. 2022 Aug 2;51(8). doi: 10.1093/ageing/afac173.
Mild cognitive impairment (MCI) is the preclinical and transitional stage between healthy ageing and dementia that may be a potential 'target' for interventions designed to delay progression to dementia. In this systematic review and meta-analysis, we assessed the prevalence of MCI worldwide in community-dwelling adults aged 50 years and older.
PubMed, Web of Science, Embase and PsycINFO database searches were conducted from their respective inception dates to 1 September 2021. Data on the overall prevalence of MCI were synthesised using random effects models.
A total of 66 articles covering 242,804 participants fulfilled study criteria for inclusion. The overall prevalence of MCI was 15.56% (95%CI: 13.24-18.03%). Prevalence rates of amnestic MCI and non-amnestic MCI were 10.03% (95%CI: 7.98-12.27%) and 8.72% (95%CI: 6.78-10.89%), respectively. The prevalence of MCI increased with age and decreased with education level. Subgroup and meta-regression analyses revealed that region of study site and male gender proportion per sample were significant correlates of MCI prevalence.
The global prevalence of MCI among community dwellers is over 15% and is affected by age, gender, education level and region of study sites. Assessment and interventions targeting MCI within at-risk population subgroups should be considered toward the prevention of dementia.
轻度认知障碍 (MCI) 是健康衰老与痴呆之间的临床前期和过渡阶段，可能是干预措施的潜在“目标”，旨在延缓向痴呆的进展。在这项系统评价和荟萃分析中，我们评估了全球社区居住的 50 岁及以上成年人中 MCI 的患病率。
从各自的创建日期到 2021 年 9 月 1 日，对 PubMed、Web of Science、Embase 和 PsycINFO 数据库进行了检索。使用随机效应模型综合 MCI 的总体患病率数据。
共有 66 篇文章涵盖了 242804 名符合纳入标准的参与者。MCI 的总体患病率为 15.56%（95%CI：13.24-18.03%）。遗忘型 MCI 和非遗忘型 MCI 的患病率分别为 10.03%（95%CI：7.98-12.27%）和 8.72%（95%CI：6.78-10.89%）。MCI 的患病率随年龄增长而增加，随教育水平降低而降低。亚组和荟萃回归分析表明，研究地点的区域和样本中的男性比例是 MCI 患病率的显著相关因素。
社区居民中 MCI 的全球患病率超过 15%，且受年龄、性别、教育水平和研究地点区域的影响。应考虑针对高危人群亚组的 MCI 评估和干预措施，以预防痴呆症。
