Zhu Tingting, Fang Fumin, Li Hao, Lei Dongyun, Man Mao-Qiang
Department of Dermatology, the First Affiliated Hospital of Soochow University, Suzhou, 215006, People's Republic of China.
Department of Dermatology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, 300120, People's Republic of China.
Clin Cosmet Investig Dermatol. 2025 Aug 27;18:2013-2023. doi: 10.2147/CCID.S539786. eCollection 2025.
Skin is more than a physical barrier; it plays a crucial role in overall health, emotional well-being, and social interactions. Beyond its primary function in protection and sensation, the skin actively influences extracutaneous systems through immune regulation, endocrine signaling, and microbiome interactions. Dermatological conditions such as psoriasis, eczema, and rosacea are linked to systemic inflammation, cardiovascular risks, and metabolic disorders, demonstrating the skin's far-reaching impact on overall health. Additionally, skin appearance affects psychological health, self-esteem, and social engagement, reinforcing its significance beyond physiology. Maintaining skin integrity in aging populations may help mitigate the progression of systemic diseases associated with inflammation and aging. Enhancing epidermal function in neonates, particularly pre-term neonates, lowers the risk of infections and mortality rates, while promoting the weight gain. Understanding these broader influences of skin can lead to more holistic therapeutic strategies, emphasizing dermatological health as a component of overall well-being. This perspective explores the connection between the cutaneous and extracutaneous conditions, and highlights the importance of improvement of cutaneous conditions in the management of some health conditions.
皮肤不仅仅是一道物理屏障；它在整体健康、情绪健康和社交互动中发挥着关键作用。除了其在保护和感觉方面的主要功能外，皮肤还通过免疫调节、内分泌信号传导和微生物群相互作用积极影响皮肤外系统。银屑病、湿疹和玫瑰痤疮等皮肤病与全身炎症、心血管风险和代谢紊乱有关，这表明皮肤对整体健康有着深远影响。此外，皮肤外观会影响心理健康、自尊和社交参与度，强化了其在生理之外的重要性。在老年人群中维持皮肤完整性可能有助于减轻与炎症和衰老相关的全身性疾病的进展。增强新生儿尤其是早产儿的表皮功能可降低感染风险和死亡率，同时促进体重增加。了解皮肤的这些更广泛影响可以带来更全面的治疗策略，强调皮肤健康是整体健康的一个组成部分。这一观点探讨了皮肤与皮肤外状况之间的联系，并强调了改善皮肤状况在某些健康状况管理中的重要性。
