Byrne J M, Camfield P R, Clark-Touesnard M, Hondas B J
J Clin Exp Neuropsychol. 1987 Aug;9(4):393-8. doi: 10.1080/01688638708405059.
A Monozygotic twin pair had febrile seizures, only one was treated with phenobarbital from 17-30 months of age. Standard intellectual and behavioral assessments were conducted during Treatment (30 months of age), and Post-Treatment (32, 41, 48, 66 months of age). Both twins showed normal global intelligence at all assessments, however, the phenobarbital twin scored lower at all assessments. Differences in specific abilities were also seen during Post-Treatment. When phenobarbital was withdrawn, the treated twin's behavior showed immediate improvement. This experience suggests that early phenobarbital treatment may affect global intelligence through the preschool period, but that the effect is not severe. Phenobarbital also may adversely affect behavior, although the effect disappears with termination of the drug.
一对同卵双胞胎都出现了高热惊厥，其中只有一人在17至30个月大时接受了苯巴比妥治疗。在治疗期间（30个月大）以及治疗后（32、41、48、66个月大）进行了标准的智力和行为评估。在所有评估中，双胞胎的整体智力均表现正常，然而，接受苯巴比妥治疗的双胞胎在所有评估中的得分都较低。在治疗后还发现了特定能力方面的差异。当停用苯巴比妥后，接受治疗的双胞胎的行为立即有所改善。这一经历表明，早期苯巴比妥治疗可能在整个学龄前阶段影响整体智力，但影响并不严重。苯巴比妥也可能对行为产生不利影响，不过随着药物停用，这种影响会消失。
