Belaisch-Allart J, Testart J, Fries N, Forman R G, Frydman R
Hum Reprod. 1987 Apr;2(3):183-5. doi: 10.1093/oxfordjournals.humrep.a136511.
Various treatments are given during the luteal phase by most IVF programmes, without any proof of their efficacy. We have performed a double-blind, randomized study with dydrogesterone (125 transfers) against placebo (133 transfers). The pregnancy rate was 21.6 versus 15.0% per transfer cycle with dydrogesterone or placebo, respectively. There was no significant difference between these figures, but taking into account the usual success rate in IVF programmes (15-20%) a difference of 5% would be significant only with two groups of 1500 subjects. This paper discusses the question of how we can come to a definite conclusion on the efficacy of hormonal supplementation during the luteal phase.
大多数试管婴儿项目在黄体期会采用各种治疗方法，但却没有任何证据证明其疗效。我们进行了一项双盲随机研究，比较了地屈孕酮（125例移植）与安慰剂（133例移植）的效果。每个移植周期中，使用地屈孕酮或安慰剂的妊娠率分别为21.6%和15.0%。这些数字之间没有显著差异，但考虑到试管婴儿项目通常的成功率（15%-20%），只有在两组各有1500名受试者的情况下，5%的差异才会具有显著性。本文讨论了如何就黄体期激素补充疗法的疗效得出明确结论这一问题。
