绝经后早期的局部和全身骨骼测量
Regional and total skeletal measurements in the early postmenopause.
作者信息
Stevenson J C, Banks L M, Spinks T J, Freemantle C, MacIntyre I, Hesp R, Lane G, Endacott J A, Padwick M, Whitehead M I
出版信息
J Clin Invest. 1987 Jul;80(1):258-62. doi: 10.1172/JCI113056.
In a cross-sectional study of 70 early postmenopausal women, regional bone measurements were compared with total body calcium (TBCa). Spinal and forearm trabecular bone were mainly related to age and time since menopause. In contrast, TBCa and forearm integral (cortical and trabecular) and cortical bone were unrelated to age, although the time since menopause also had some influence. Forearm integral and cortical bone measurements were quite well correlated with TBCa (r = 0.84 and 0.73, respectively, P less than 0.001). The correlation between spinal bone measurements and any of the forearm measurements, even purely trabecular bone, was weak (r less than 0.52, P less than 0.001). Our results show quite clearly that forearm bone measurements cannot be used to predict bone density in the vertebrae. Loss of ovarian function affects bone in general, and trabecular bone in particular. Bone measurements at specific anatomical sites are clearly necessary for studies of metabolic bone diseases and their response to treatment.
在一项对70名绝经后早期女性的横断面研究中，对局部骨测量值与全身钙含量（TBCa）进行了比较。脊柱和前臂小梁骨主要与年龄及绝经后的时间有关。相比之下，TBCa、前臂整体骨（皮质骨和小梁骨）及皮质骨与年龄无关，不过绝经后的时间也有一定影响。前臂整体骨及皮质骨测量值与TBCa的相关性相当好（r分别为0.84和0.73，P<0.001）。脊柱骨测量值与任何前臂测量值之间的相关性较弱，即便与单纯的小梁骨测量值相比也是如此（r<0.52，P<0.001）。我们的结果清楚表明，前臂骨测量值不能用于预测椎体的骨密度。卵巢功能丧失总体上会影响骨骼，尤其是小梁骨。对于代谢性骨病及其治疗反应的研究，特定解剖部位的骨测量显然是必要的。
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